J
Julien Bryois
Researcher at Hoffmann-La Roche
Publications - 2
Citations - 16
Julien Bryois is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Cell type & Genome-wide association study. The author has co-authored 2 publications.
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Cell-type specific cis-eQTLs in eight brain cell-types identifies novel risk genes for human brain disorders
Julien Bryois,Daniela Calini,W. Macnair,L. Foo,E. Urich,W. Ortmann,V. A. Iglesias,S. Selvaraj,Erik Nutma,Manuel C. Marzin,Sandra Amor,Sandra Amor,Anna Williams,Gonçalo Castelo-Branco,Vilas Menon,P. L. De Jager,Dheeraj Malhotra +16 more
TL;DR: In this paper, the authors performed an eQTL analysis using single nuclei RNA-seq from 196 individuals in eight central nervous system (CNS) cell types and identified 6108 eGenes, a substantial fraction of which show cell-type specific effects, with strongest effects in microglia.
Posted ContentDOI
Defining the architecture of cerebrospinal fluid cellular communities in neuroinflammatory diseases
Tina Roostaei,Claudiu I. Diaconu,Hanane Touil,Claire Harbison,Ya Zhang,Samantha Epstein,John F. Tuddenham,Kiran T. Thakur,Julien Bryois,Heinz Wiendl,Gerd Meyer zu Hörste,Dheeraj Malhotra,Claire S Riley,Vilas Menon,Philip L. De Jager +14 more
TL;DR: In this paper, the authors provided an updated atlas of the immune cells present in human CSF in MS and other neuroinflammatory conditions, including novel lymphoid and myeloid cell clusters.