J
Julien Nicolas
Researcher at Université Paris-Saclay
Publications - 149
Citations - 17518
Julien Nicolas is an academic researcher from Université Paris-Saclay. The author has contributed to research in topics: Polymerization & Copolymer. The author has an hindex of 51, co-authored 137 publications receiving 15150 citations. Previous affiliations of Julien Nicolas include Arkema & University of Warwick.
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Journal ArticleDOI
Pulmonary Surfactant Protein A-Mediated Enrichment of Surface-Decorated Polymeric Nanoparticles in Alveolar Macrophages.
Christian A. Ruge,Hervé Hillaireau,Nadège Grabowski,Moritz Beck-Broichsitter,Olga Cañadas,Nicolas Tsapis,Cristina Casals,Julien Nicolas,Elias Fattal +8 more
TL;DR: It is demonstrated for the first time that the pool of nanoparticles available to lung cells can be changed after surface modification, using a biomimetic approach.
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Simple Synthesis of Cladribine-Based Anticancer Polymer Prodrug Nanoparticles with Tunable Drug Delivery Properties
Yinyin Bao,Tanguy Boissenot,Elise Guégain,Didier Desmaële,Simona Mura,Patrick Couvreur,Julien Nicolas +6 more
TL;DR: Nanoparticles were formed by nanoprecipitation into water of the resulting CdA-PI conjugates and exhibited long-term colloidal stability in different media, tunable colloidal characteristics, drug release profiles, and anticancer activities in vitro, simply by modulating the drug/polymer linker, the polymer chain length and the formulation parameters.
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Significant Tumor Growth Inhibition from Naturally Occurring Lipid-Containing Polymer Prodrug Nanoparticles Obtained by the Drug-Initiated Method
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Protein-Functionalized Nanoparticles Derived from End-Functional Polymers and Polymer Prodrugs for Crossing the Blood-Brain Barrier
Alysia Cox,Daniele Vinciguerra,Francesca Re,Roberta Dal Magro,Simona Mura,Massimo Masserini,Patrick Couvreur,Julien Nicolas +7 more
TL;DR: A new and facile synthetic approach is established for the surface-functionalization of polymer nanoparticles for brain delivery purposes and it was shown that bare NPs without the drug exhibited significant permeability and cellular uptake, which were further enhanced by NP surface functionalization with α2-macroglobulin.
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Telechelic polymers from reversible-deactivation radical polymerization for biomedical applications.
TL;DR: The main strategies for the design of telechelic polymers synthesized by reversible-activation radical polymerization for biomedical applications are covered spanning from drug delivery and targeting to theranostics and sensing.