J
Julien Nicolas
Researcher at Université Paris-Saclay
Publications - 149
Citations - 17518
Julien Nicolas is an academic researcher from Université Paris-Saclay. The author has contributed to research in topics: Polymerization & Copolymer. The author has an hindex of 51, co-authored 137 publications receiving 15150 citations. Previous affiliations of Julien Nicolas include Arkema & University of Warwick.
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From poly(alkyl cyanoacrylate) to squalene as core material for the design of nanomedicines.
TL;DR: The development of a novel type of NP with higher drug loadings and lower burst release was tackled by the discovery of squalene-based nanomedicines where the drug is covalently linked to the lipid derivative and the resulting conjugate is self-assembled into NPs.
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Cyclopentyl methyl ether as a green solvent for reversible-addition fragmentation chain transfer and nitroxide-mediated polymerizations
Carlos M. R. Abreu,Pedro Maximiano,Tamaz Guliashvili,Julien Nicolas,Arménio C. Serra,Jorge F. J. Coelho +5 more
TL;DR: In this paper, cyclopentyl methyl ether (CPME) was successfully used as an environmentally friendly alternative to the regularly employed organic solvents (e.g., tetrahydrofuran (THF), dimethyl sulfoxide (DMSO), dichloromethane (DCM) and dimethylformamide (DMF)) for the reversible-addition fragmentation chain transfer (RAFT) polymerization and nitroxide-mediated polymerization (NMP) of vinyl chloride (VC) and styrene (S).
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A facile route to heterotelechelic polymer prodrug nanoparticles for imaging, drug delivery and combination therapy.
Daniele Vinciguerra,Stéphanie Denis,Julie Mougin,Merel Jacobs,Yohann Guillaneuf,Simona Mura,Patrick Couvreur,Julien Nicolas +7 more
TL;DR: A facile and general synthetic methodology has been developed to prepare high drug loading heterotelechelic polymer prodrug nanoparticles that are nanoparticles obtained by formulation of linear polymers bearing two different molecules at both extremities.
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DFT-calculation-assisted prediction of the copolymerization between cyclic ketene acetals and traditional vinyl monomers
Antoine Tardy,Noémie Gil,Christopher M. Plummer,Chen Zhu,Simon Harrisson,Simon Harrisson,Didier Siri,Julien Nicolas,Didier Gigmes,Yohann Guillaneuf,Catherine Lefay +10 more
TL;DR: In this paper, the reactivity of cyclic ketene acetals and common vinyl monomers has been analyzed and it has been shown that common vinyl copolymers can be obtained with reactivity ratios close to 0.
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On the structure–control relationship of amide-functionalized SG1-based alkoxyamines for nitroxide-mediated polymerization and conjugation
Elise Guégain,Vianney Delplace,Thomas Trimaille,Didier Gigmes,Didier Siri,Sylvain R. A. Marque,Yohann Guillaneuf,Julien Nicolas +7 more
TL;DR: In this paper, a wide range of amide-functionalized alkoxyamines (a functionality often obtained after conjugation from COOH- and N-succinimidyl-containing alkoxyamine) based on SG1 (N-tert-butyl-N-(1-diethyl phosphono-2,2-dimethylpropyl) nitroxide) have been synthesized and their dissociation rate constants have been determined to rationalize their reactivity.