Julien Nicolas

TL;DR: Following PEGylation, the Gem‐Sq nanoassemblies displayed superior in vitro anticancer activity on gem citabine‐resistant leukemia L1210 10K cells than either their non‐PEGylated counterparts or gemcitabine alone.

TL;DR: Following a cytotoxicity study over three different cell lines that represent important mammalian cell types, these polymers were shown to be noncytotoxic even at very high doses without any other purification step than a simple precipitation.

TL;DR: This Review Article will give an in-depth overview of the design and the biological evaluation of Cathepsin-sensitive drug delivery systems and their application in different pathologies including cancer before discussing Cathepsypsin B-cleavable prodrugs under clinical trials.

TL;DR: Well-defined fluorescent, α-functional polymethacrylates with PEG side chains were readily designed by nitroxide-mediated polymerization (NMP) from N-hydroxysuccinimidyl (NHS) ester-containing alkoxyamines based on the nitroxides SG1 and represent the very first example of peptide/protein PEGylation with functional polymers derived from NMP.

TL;DR: In this article, controlled free-radical homopolymerization of n-butyl acrylate was studied in aqueous miniemulsions at 112 and 125 °C with a low molar mass alkoxyamine unimolecular initiator and an acyclic β-phosphonylated nitroxide mediator, also called SG1.