Yuanyuan Wu

TL;DR: The results strongly suggest that Nkx2.2 regulates the differentiation and/or maturation, but not the initial specification, of oligodendrocyte progenitors, and that overproduction of Nk X.2 protein in fibroblast cells can induce gene expression from the proteolipid protein promoter.

TL;DR: The data provide strong evidence for the existence of a CD44+ ARP in the developing nervous system, which can be generated from GRP cells in mass or clonal cultures and in vivo after transplantation, suggesting a sequential differentiation of neuroepithelial stem cells to GRPs to ARPs and then to astrocytes.

TL;DR: It is shown that NEP cells can be enriched by depleting differentiating cells that express E-NCAM or A2B5 immunoreactivity and a spectrum of markers used in combination can reliably distinguish multipotent NSCs from other precursor cells as well as differentiated cells present in the CNS.

TL;DR: A sequential model in which motoneuron and oligodendrocyte precursors are sequentially generated in vivo from neuroepithelial stem cells, but do not share a common lineage-restricted progenitor is supported.

TL;DR: It is shown that proliferating stem cells in the developing neural tube do not express any glial markers at E10.5, however, glial precursors have begun to differentiate and at least two regions of the ventral neural tube containing glial precursor cells can be distinguished by E11.