J
Jun Hasegawa
Researcher at Institute of Medical Science
Publications - 2
Citations - 936
Jun Hasegawa is an academic researcher from Institute of Medical Science. The author has contributed to research in topics: Sequestosome-1 Protein & Phosphorylation. The author has an hindex of 2, co-authored 2 publications receiving 731 citations.
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Journal ArticleDOI
Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.
Yoshinobu Ichimura,Satoshi Waguri,Yu-shin Sou,Shun Kageyama,Jun Hasegawa,Ryosuke Ishimura,Tetsuya Saito,Yinjie Yang,Tsuguka Kouno,Toshiaki Fukutomi,Takayuki Hoshii,Atsushi Hirao,Kenji Takagi,Tsunehiro Mizushima,Hozumi Motohashi,Myung-Shik Lee,Tamotsu Yoshimori,Keiji Tanaka,Masayuki Yamamoto,Masaaki Komatsu +19 more
TL;DR: It is shown that phosphorylation of the autophagy-adaptor protein p62 markedly increases p62's binding affinity for Keap1, an adaptor of the Cul3-ubiquitin E3 ligase complex responsible for degrading Nrf2, and that inhibitors of the interaction between phosphorylated p62 and Keap 1 have potential as therapeutic agents against human HCC.
Journal ArticleDOI
Crystal structure of the ubiquitin-associated (UBA) domain of p62 and its interaction with ubiquitin.
Shin Isogai,Daichi Morimoto,Kyouhei Arita,Satoru Unzai,Takeshi Tenno,Jun Hasegawa,Yu-shin Sou,Masaaki Komatsu,Keiji Tanaka,Masahiro Shirakawa,Hidehito Tochio +10 more
TL;DR: The crystal structure of the UBA domain of mouse p62 and the solution structure of its ubiquitin-bound form reveal an autoinhibitory mechanism in the p62 UBAdomain and suggest that autoinhibition plays a role in the function of p62.