Jun Komano

TL;DR: It is shown that NETs capture human immunodeficiency virus (HIV)-1 and promote HIV-1 elimination through myeloperoxidase and α-defensin and that NET formation is an antiviral response that is counteracted by HIV- 1.

TL;DR: It is demonstrated that one viral protein found in allEBV-associated malignancies, Epstein-Barr nuclear antigen 1 (EBNA-1), is required for survival of one of these cancers, EBV-positive Burkitt's lymphoma, and by extension, for the other B cell tumors with which EBV is associated.

TL;DR: The existence of an Arp2/3 complex-dependent event during the early phase of the life cycles of both primate lentiviruses and IMV is suggested, suggesting a potential chemotherapeutic intervention for acquired immunodeficiency syndrome (AIDS).

TL;DR: The results indicate that SOCS1 is a crucial host factor that regulates the intracellular dynamism of HIV-1 Gag and could therefore be a potential new therapeutic target for AIDS and its related disorders.

TL;DR: The results suggest that the MSD of gp41 has a relatively wide but not unlimited tolerance for mutations and plays a critical role in membrane fusion as well as in other steps of Env biogenesis.