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Yoshiyuki Yokomaku
Researcher at Chiba University
Publications - 58
Citations - 924
Yoshiyuki Yokomaku is an academic researcher from Chiba University. The author has contributed to research in topics: Medicine & Acquired immunodeficiency syndrome (AIDS). The author has an hindex of 15, co-authored 48 publications receiving 768 citations.
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Journal ArticleDOI
The APOBEC3C crystal structure and the interface for HIV-1 Vif binding.
Shingo Kitamura,Hirotaka Ode,Masaaki Nakashima,Mayumi Imahashi,Yuriko Naganawa,Teppei Kurosawa,Yoshiyuki Yokomaku,Takashi Yamane,Nobuhisa Watanabe,Atsuo Suzuki,Wataru Sugiura,Yasumasa Iwatani +11 more
TL;DR: A high-resolution crystal structure of APOBEC3C is reported and the role of a shallow cavity composed of hydrophobic or negatively charged residues between the α2 and α3 helices is revealed, which could provide insight into Vif-A3 interactions and could lead to the development of new pharmacologic anti–HIV-1 compounds.
Journal ArticleDOI
Role of the Specific Amino Acid Sequence of the Membrane-Spanning Domain of Human Immunodeficiency Virus Type 1 in Membrane Fusion
TL;DR: The results suggest that the MSD of gp41 has a relatively wide but not unlimited tolerance for mutations and plays a critical role in membrane fusion as well as in other steps of Env biogenesis.
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HIV-2 CRF01_AB: first circulating recombinant form of HIV-2.
Shiro Ibe,Yoshiyuki Yokomaku,Teiichiro Shiino,Rie Tanaka,Junko Hattori,Seiichiro Fujisaki,Yasumasa Iwatani,Naoto Mamiya,Makoto Utsumi,Shingo Kato,Motohiro Hamaguchi,Wataru Sugiura,Wataru Sugiura +12 more
TL;DR: This ectopic observation of the virus outside its original endemic area suggests an ongoing global spread of HIV-2 CRF01_AB, the first circulating recombinant form of HIV, which was identified recently in Japan.
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Structural Insights into HIV-1 Vif-APOBEC3F Interaction.
Masaaki Nakashima,Hirotaka Ode,Takashi Kawamura,Shingo Kitamura,Yuriko Naganawa,Hiroaki Awazu,Shinya Tsuzuki,Kazuhiro Matsuoka,Michiko Nemoto,Atsuko Hachiya,Wataru Sugiura,Yoshiyuki Yokomaku,Nobuhisa Watanabe,Yasumasa Iwatani +13 more
TL;DR: Structural insights are provided into the A3F-Vif interaction mechanism, which will provide an important basis for development of novel anti-HIV-1 drugs using cellular cytidine deaminases.
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Trends in transmitted drug-resistant HIV-1 and demographic characteristics of newly diagnosed patients: nationwide surveillance from 2003 to 2008 in Japan.
Junko Hattori,Teiichiro Shiino,Hiroyuki Gatanaga,Shigeru Yoshida,Dai Watanabe,Rumi Minami,Kenji Sadamasu,Makiko Kondo,Haruyo Mori,Mikio Ueda,Masao Tateyama,Atsuhisa Ueda,Shingo Kato,Ito Toshihiro,Masayasu Oie,Noboru Takata,Tsunefusa Hayashida,Mami Nagashima,Masakazu Matsuda,Shiro Ibe,Yasuo Ota,Satoru Sasaki,Yoshiaki Ishigatsubo,Yoshinari Tanabe,Ichiro Koga,Yoko Kojima,Masahiro Yamamoto,Jiro Fujita,Yoshiyuki Yokomaku,Takao Koike,Takuma Shirasaka,Shinichi Oka,Wataru Sugiura,Wataru Sugiura +33 more
TL;DR: The prevalence of drug-resistant HIV-1 among newly diagnosed patients, consisting mainly of Japanese men in their late-30s and infected through male-to-male sexual contacts, followed an increasing trend in the 6-year study period, with T215 revertants being the most abundant.