S
Shin-ichiro Hattori
Researcher at National Institutes of Health
Publications - 33
Citations - 1528
Shin-ichiro Hattori is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Protease & Medicine. The author has an hindex of 8, co-authored 25 publications receiving 727 citations.
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Journal ArticleDOI
Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development.
Masaki Imai,Kiyoko Iwatsuki-Horimoto,Masato Hatta,Samantha Loeber,Peter Halfmann,Noriko Nakajima,Tokiko Watanabe,Michiko Ujie,Kenta Takahashi,Mutsumi Ito,Shinya Yamada,Shufang Fan,Shiho Chiba,Makoto Kuroda,Lizheng Guan,Kosuke Takada,Tammy Armbrust,Aaron Balogh,Yuri Furusawa,Moe Okuda,Hiroshi Ueki,Atsuhiro Yasuhara,Yuko Sakai-Tagawa,Tiago J. S. Lopes,Tiago J. S. Lopes,Maki Kiso,Seiya Yamayoshi,Noriko Kinoshita,Norio Ohmagari,Shin-ichiro Hattori,Makoto Takeda,Hiroaki Mitsuya,Florian Krammer,Tadaki Suzuki,Yoshihiro Kawaoka,Yoshihiro Kawaoka +35 more
TL;DR: It is found that SARS-CoV-2 isolates replicate efficiently in the lungs of Syrian hamsters and cause severe pathological lesions in the lung of these animals similar to commonly reported imaging features of COVID-19 patients with pneumonia.
Journal ArticleDOI
Characterization and antiviral susceptibility of SARS-CoV-2 Omicron BA.2
Ryuta Uraki,Maki Kiso,Shun Iida,Masaki Imai,Emi Takashita,Makoto Kuroda,Peter Halfmann,Samantha Loeber,Tadashi Maemura,Seiya Yamayoshi,Seiichiro Fujisaki,Zhongde Wang,Mutsumi Ito,Michiko Ujie,Kiyoko Iwatsuki-Horimoto,Yuri Furusawa,R. Wright,Zhenlu Chong,Seiya Ozono,Atsuhiro Yasuhara,Hiroshi Ueki,Yuko Sakai-Tagawa,Rongxiu Li,Yanan Liu,Deanna Larson,Michiko Koga,Takeya Tsutsumi,Eisuke Adachi,Makoto Saito,Shinya Yamamoto,Masao Hagihara,Keiko Mitamura,Tetsuro Sato,Masayuki Hojo,Shin-ichiro Hattori,Kenji Maeda,Riccardo Valdez,Pamela E. Bennett-Baker,Zijin Chu,Dawson Davis,Theresa Kowalski-Dobson,Ashley Eckard,Carmen Gherasim,Wolf Gremel,Kathy Lindsey,David M Manthei,A. Meyers,Julio Zuniga Moya,Aaron Rico,Emily Stoneman,Victoria Le Blanc,Savanna Sneeringer,Lauren Warsinske,Moe Okuda,Jurika Murakami,C. Duong,Sucheta Godbole,Daniel C. Douek,Ken Maeda,Shinji Watanabe,Aubree Gordon,Norio Ohmagari,Hiroshi Yotsuyanagi,Michael S. Diamond,Hideki Hasegawa,Hiroaki Mitsuya,Tadaki Suzuki,Yoshihiro Kawaoka +67 more
TL;DR: In this article , the authors evaluated the replicative ability and pathogenicity of authentic infectious BA.2 isolates in immunocompetent and human ACE2-expressing mice and hamsters.
Posted ContentDOI
Characterization and antiviral susceptibility of SARS-CoV-2 Omicron/BA.2
Yoshihiro Kawaoka,Ryuta Uraki,Maki Kiso,Shun Iida,Masaki Imai,Emi Takashita,Makoto Kuroda,Peter Halfmann,Samantha Loeber,Tadashi Maemura,Seiya Yamayoshi,Seiichiro Fujisaki,Zhongde Wang,Mutsumi Ito,Michiko Ujie,Kiyoko Iwatsuki-Horimoto,Yuri Furusawa,R. Wright,Zhenlu Chong,Seiya Ozono,Atsuhiro Yasuhara,Hiroshi Ueki,Yuko Sakai,Rongxiu Li,Yanan Liu,Deanna Larson,Michiko Koga,Takeya Tsutsumi,Eisuke Adachi,Makoto Saito,Shinya Yamamoto,Shohei Matsubara,Masao Hagihara,Keiko Mitamura,Tetsuro Sato,Masayuki Hojo,Shin-ichiro Hattori,Kenji Maeda,Moe Okuda,Jurika Murakami,C. Duong,Sucheta Godbole,Daniel C. Douek,Shinji Watanabe,Norio Ohmagari,Hiroshi Yotsuyanagi,Michael S. Diamond,Hideki Hasegawa,Hiroaki Mitsuya,Tadaki Suzuki +49 more
TL;DR: Findings suggest that the replication and pathogenicity of BA.2 is comparable to that ofBA.1 in rodents and that several therapeutic monoclonal antibodies and antiviral compounds are effective against Omicron/BA.2 variants.
Journal ArticleDOI
SOCS1 is an inducible host factor during HIV-1 infection and regulates the intracellular trafficking and stability of HIV-1 Gag
Akihide Ryo,Naomi Tsurutani,Kenji Ohba,Ryuichiro Kimura,Jun Komano,Mayuko Nishi,Hiromi Soeda,Shin-ichiro Hattori,Kilian Perrem,Mikio Yamamoto,Joe Chiba,Jun Ichi Mimaya,Kazuhisa Yoshimura,Shuzo Matsushita,Mitsuo Honda,Akihiko Yoshimura,Tatsuya Sawasaki,Ichiro Aoki,Yuko Morikawa,Naoki Yamamoto +19 more
TL;DR: The results indicate that SOCS1 is a crucial host factor that regulates the intracellular dynamism of HIV-1 Gag and could therefore be a potential new therapeutic target for AIDS and its related disorders.
Journal ArticleDOI
Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity
Haydar Bulut,Shin-ichiro Hattori,Hiromi Aoki-Ogata,Hironori Hayashi,Debananda Das,Manabu Aoki,David A. Davis,Kanury V. S. Rao,Prasanth R. Nyalapatla,Arun K. Ghosh,Hiroaki Mitsuya,Hiroaki Mitsuya +11 more
TL;DR: X-ray structural analyses of the PIs complexed with wild-type Protease (PR WT ) and highly-multi-PI-resistance-associated PR DRV R P51 revealed that the PI better adapt to structural plasticity in PR with resistance-associated amino acid substitutions by formation of optimal sulfur bond and adaptation of cyclopropyl ring in the S2′-subsite.