J
Jun Komano
Researcher at National Institutes of Health
Publications - 74
Citations - 2445
Jun Komano is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Virus & Viral replication. The author has an hindex of 24, co-authored 73 publications receiving 2178 citations.
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Journal ArticleDOI
Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-1.
Tatsuya Saitoh,Jun Komano,Yasunori Saitoh,Takuma Misawa,Michihiro Takahama,Tatsuya Kozaki,Takuya Uehata,Hidenori Iwasaki,Hiroko Omori,Shoji Yamaoka,Naoki Yamamoto,Shizuo Akira +11 more
TL;DR: It is shown that NETs capture human immunodeficiency virus (HIV)-1 and promote HIV-1 elimination through myeloperoxidase and α-defensin and that NET formation is an antiviral response that is counteracted by HIV- 1.
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Epstein-Barr virus provides a survival factor to Burkitt's lymphomas
TL;DR: It is demonstrated that one viral protein found in allEBV-associated malignancies, Epstein-Barr nuclear antigen 1 (EBNA-1), is required for survival of one of these cancers, EBV-positive Burkitt's lymphoma, and by extension, for the other B cell tumors with which EBV is associated.
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Inhibiting the Arp2/3 Complex Limits Infection of Both Intracellular Mature Vaccinia Virus and Primate Lentiviruses
TL;DR: The existence of an Arp2/3 complex-dependent event during the early phase of the life cycles of both primate lentiviruses and IMV is suggested, suggesting a potential chemotherapeutic intervention for acquired immunodeficiency syndrome (AIDS).
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SOCS1 is an inducible host factor during HIV-1 infection and regulates the intracellular trafficking and stability of HIV-1 Gag
Akihide Ryo,Naomi Tsurutani,Kenji Ohba,Ryuichiro Kimura,Jun Komano,Mayuko Nishi,Hiromi Soeda,Shin-ichiro Hattori,Kilian Perrem,Mikio Yamamoto,Joe Chiba,Jun Ichi Mimaya,Kazuhisa Yoshimura,Shuzo Matsushita,Mitsuo Honda,Akihiko Yoshimura,Tatsuya Sawasaki,Ichiro Aoki,Yuko Morikawa,Naoki Yamamoto +19 more
TL;DR: The results indicate that SOCS1 is a crucial host factor that regulates the intracellular dynamism of HIV-1 Gag and could therefore be a potential new therapeutic target for AIDS and its related disorders.
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Role of the Specific Amino Acid Sequence of the Membrane-Spanning Domain of Human Immunodeficiency Virus Type 1 in Membrane Fusion
TL;DR: The results suggest that the MSD of gp41 has a relatively wide but not unlimited tolerance for mutations and plays a critical role in membrane fusion as well as in other steps of Env biogenesis.