J
Jun Kyoung Choe
Publications - 4
Citations - 46
Jun Kyoung Choe is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 1 publications receiving 38 citations.
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Journal ArticleDOI
High-Throughput Sequencing and De Novo Assembly of Brassica oleracea var. Capitata L. for Transcriptome Analysis
TL;DR: The building of reliable transcriptomic data based on high-throughput sequencing technologies for cabbage will enhance the quality of gene annotation and functional analysis of the cabbage genome and serve as a material basis for future genomic research on cabbage.
Journal ArticleDOI
Discovery of small molecule inhibitors that effectively disrupt IQGAP1-Cdc42 interaction in breast cancer cells
Samar Sayedyahossein,Jessica Smith,Elena Barnaeva,Zhigang Li,Jun Kyoung Choe,Michael Ronzetti,Christopher R. Dextras,Xin Hu,Juan J. Marugan,Noel Southall,Bolormaa Baljinnyam,Louise Thines,Andy D. Tran,Marc Ferrer,David B. Sacks +14 more
TL;DR: In this article , the small GTPase Cdc42 is an integral component of the cytoskeleton, and its dysregulation leads to pathophysiological conditions, such as cancer.
Posted ContentDOI
Allosteric binders of ACE2 are promising anti-SARS-CoV-2 agents
Joshua E. Hochuli,Sankalp Jain,Cleber C. Melo-Filho,Zoe L Sessions,Tesia Bobrowski,Jun Kyoung Choe,John Zheng,Richard T. Eastman,Daniel C. Talley,Ganesha Rai,Anton Simeonov,Alexander Tropsha,Eugene N. Muratov,Bolormaa Baljinnyam,Alexey V. Zakharov +14 more
TL;DR: Five compounds that bind the human ACE2 protein can interrupt SARS-CoV-2 replication without damaging ACE2’s natural enzymatic function, and serve as a strong starting point for both development of acute treatments for COVID-19 and research into the mechanism of infection.
Journal ArticleDOI
Allosteric Binders of ACE2 Are Promising Anti-SARS-CoV-2 Agents
Joshua E. Hochuli,Sankalp Jain,Cleber C. Melo-Filho,Zoe L Sessions,Tesia Bobrowski,Jun Kyoung Choe,John Zheng,Richard T. Eastman,Daniel C. Talley,Ganesha Rai,Anton Simeonov,Alexander Tropsha,Eugene N. Muratov,Bolormaa Baljinnyam,Alexey V. Zakharov +14 more
TL;DR: Investigation of whether compounds that bind the human angiotensin-converting enzyme 2 (ACE2) protein can decrease SARS-CoV-2 replication without impacting ACE2’s natural enzymatic function finds five compounds inhibit the viral life cycle in human cells.