J
Juan J. Marugan
Researcher at National Institutes of Health
Publications - 190
Citations - 6214
Juan J. Marugan is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Receptor & Chemistry. The author has an hindex of 39, co-authored 170 publications receiving 4925 citations. Previous affiliations of Juan J. Marugan include Northwestern University & Icahn School of Medicine at Mount Sinai.
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Journal ArticleDOI
Noncanonical TGFβ Signaling Contributes to Aortic Aneurysm Progression in Marfan Syndrome Mice
Tammy M. Holm,Jennifer P Habashi,Jefferson J. Doyle,Djahida Bedja,Yichun Chen,Christel Van Erp,Mark E. Lindsay,David Kim,Florian Schoenhoff,Ronald D. Cohn,Bart Loeys,Craig J. Thomas,Samarjit Patnaik,Juan J. Marugan,Daniel P. Judge,Harry C. Dietz +15 more
TL;DR: Noncanonical (Smad-independent) TGFβ signaling is a prominent driver of aortic disease in MFS mice, and inhibition of the ERK1/2 or JNK1 pathways is a potential therapeutic strategy for the disease.
Journal ArticleDOI
MCOLN1 is a ROS sensor in lysosomes that regulates autophagy
Xiaoli Zhang,Xiping Cheng,Lu Yu,Junsheng Yang,Junsheng Yang,Raul Calvo,Samarjit Patnaik,Xin Hu,Qiong Gao,Meimei Yang,Maria Lawas,Markus Delling,Juan J. Marugan,Marc Ferrer,Haoxing Xu +14 more
TL;DR: It is shown that reactive oxygen species (ROS) activate TFEB via a lysosomal Ca2+-dependent mechanism independent of mTOR, which triggers calcineurin-dependent T FEB-nuclear translocation, autophagy induction and lysOSome biogenesis.
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Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons
Joseph R. Mazzulli,Joseph R. Mazzulli,Friederike Zunke,Taiji Tsunemi,Taiji Tsunemi,Nicholas J. Toker,Sohee Jeon,Lena F. Burbulla,Lena F. Burbulla,Samarjit Patnaik,Ellen Sidransky,Juan J. Marugan,Carolyn M. Sue,Dimitri Krainc,Dimitri Krainc +14 more
TL;DR: Results indicate that enhancement of a single lysosomal hydrolase, GCase, can effectively reduce α-syn and provide therapeutic benefit in human midbrain neurons, and suggests that GCase activators may prove beneficial as treatments for PD and related synucleinopathies.
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High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer
Amrita Datta,Hogyoung Kim,Lauren McGee,Adedoyin Johnson,Sudha Talwar,Juan J. Marugan,Noel Southall,Xin Hu,Madhu Lal,Debasis Mondal,Marc Ferrer,Asim B. Abdel-Mageed +11 more
TL;DR: The findings implicate the potential utility of drug-repurposing as novel adjunct therapeutic strategies in advanced cancer.
Journal ArticleDOI
A New Glucocerebrosidase Chaperone Reduces α-Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism
Elma Aflaki,Daniel K. Borger,Nima Moaven,Barbara K. Stubblefield,Steven A. Rogers,Samarjit Patnaik,Frank J. Schoenen,Wendy Westbroek,Wei Zheng,Patricia Sullivan,Hideji Fujiwara,Rohini Sidhu,Zayd M. Khaliq,Grisel Lopez,David S. Goldstein,Daniel S. Ory,Juan J. Marugan,Ellen Sidransky +17 more
TL;DR: Dopaminergic neurons were generated from iPSC lines derived from patients with Gaucher disease with and without parkinsonism, suggesting that noninhibitory small-molecule chaperones of glucocerebrosidase may prove useful for the treatment of Parkinson disease.