J
Jun Ueda
Researcher at Kyoto University
Publications - 5
Citations - 101
Jun Ueda is an academic researcher from Kyoto University. The author has contributed to research in topics: Parkinson's disease & Hyposmia. The author has an hindex of 2, co-authored 5 publications receiving 32 citations.
Papers
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Journal ArticleDOI
α-Synuclein BAC transgenic mice exhibit RBD-like behaviour and hyposmia: a prodromal Parkinson’s disease model
Tomoyuki Taguchi,Masashi Ikuno,Mari Hondo,Laxmi Kumar Parajuli,Katsutoshi Taguchi,Jun Ueda,Masanori Sawamura,Shinya Okuda,Etsuro Nakanishi,Junko Hara,Norihito Uemura,Yusuke Hatanaka,Takashi Ayaki,Shuichi Matsuzawa,Masaki Tanaka,Omar M. A. El-Agnaf,Masato Koike,Masashi Yanagisawa,Maiko T. Uemura,Hodaka Yamakado,Ryosuke Takahashi +20 more
TL;DR: A novel mouse model of prodromal Parkinson's disease that showed RBD-like behaviour and hyposmia without motor symptoms is created and an expression pattern of human α-synuclein very similar to that of endogenous mouse α- synuclein is shown.
Journal ArticleDOI
α-Synuclein Spread from Olfactory Bulb Causes Hyposmia, Anxiety, and Memory Loss in BAC-SNCA Mice.
Norihito Uemura,Norihito Uemura,Jun Ueda,Toru Yoshihara,Masashi Ikuno,Maiko T. Uemura,Maiko T. Uemura,Hodaka Yamakado,Masahide Asano,John Q. Trojanowski,Ryosuke Takahashi +10 more
TL;DR: In this paper, the authors examined the clinicopathological contribution of α-synuclein spread from the olfactory bulb to the lower brain stem and showed that α-Syn spread from olfia to the brain regions that are included in the limbic system and have connections with it, leading to the development of hyposmia, anxiety and memory loss.
Journal ArticleDOI
Perampanel Inhibits α-Synuclein Transmission in Parkinson's Disease Models
Jun Ueda,Norihito Uemura,Masanori Sawamura,Tomoyuki Taguchi,Masashi Ikuno,Seiji Kaji,Yosuke Taruno,Shuichi Matsuzawa,Hodaka Yamakado,Ryosuke Takahashi +9 more
TL;DR: In this paper, perampanel inhibited the development of α-synuclein pathology in mouse primary hippocampal neurons transduced with α-Synuclein preformed fibrils by inhibiting macropinocytosis in a neuronal activity-dependent manner.
Journal ArticleDOI
BCAS1-positive immature oligodendrocytes are affected by the α-synuclein-induced pathology of multiple system atrophy.
Seiji Kaji,Takakuni Maki,Jun Ueda,Tomoyuki Ishimoto,Yutaka Inoue,Ken Yasuda,Masanori Sawamura,Rie Hikawa,Takashi Ayaki,Hodaka Yamakado,Ryosuke Takahashi +10 more
TL;DR: Oligodendroglial maturation and myelination are impaired in the BCAS1-positive phase of MSA brains, which may lead to the insufficient replacement of defective oligodendrocytes.
Book ChapterDOI
α-Synuclein Propagation Mouse Models of Parkinson's Disease.
TL;DR: In this paper, a methodology for the generation of α-synuclein preformed fibrils (PFFs) and the surgery on mice was described, which can recapitulate LB-like inclusions and the subsequent intercellular transmission of αSyn pathology.