O
Omar M. A. El-Agnaf
Researcher at Khalifa University
Publications - 177
Citations - 14544
Omar M. A. El-Agnaf is an academic researcher from Khalifa University. The author has contributed to research in topics: Alpha-synuclein & Parkinson's disease. The author has an hindex of 52, co-authored 155 publications receiving 11674 citations. Previous affiliations of Omar M. A. El-Agnaf include United Arab Emirates University & St George's Hospital.
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Journal ArticleDOI
Diagnosis and management of dementia with Lewy bodies Fourth consensus report of the DLB Consortium
Ian G. McKeith,Bradley F. Boeve,Dennis W. Dickson,Glenda M. Halliday,John-Paul Taylor,Daniel Weintraub,Dag Aarsland,Dag Aarsland,James E. Galvin,Johannes Attems,Johannes Attems,Clive Ballard,Clive Ballard,Ashley Bayston,Ashley Bayston,Thomas G. Beach,Thomas G. Beach,Frédéric Blanc,Nicolaas Bohnen,Nicolaas Bohnen,Nicolaas Bohnen,Laura Bonanni,Laura Bonanni,Jose Bras,Jose Bras,Patrik Brundin,Patrik Brundin,David J. Burn,David J. Burn,Alice Chen-Plotkin,John E. Duda,Omar M. A. El-Agnaf,Howard Feldman,Tanis J. Ferman,Dominic Ffytche,Hiroshige Fujishiro,Douglas Galasko,Jennifer G. Goldman,Stephen N. Gomperts,Neill R. Graff-Radford,Lawrence S. Honig,Lawrence S. Honig,Alex Iranzo,Alex Iranzo,Alex Iranzo,Kejal Kantarci,Daniel I. Kaufer,Walter Kukull,Virginia M.Y. Lee,James B. Leverenz,James B. Leverenz,Simon J.G. Lewis,Carol F. Lippa,Carol F. Lippa,Angela Lunde,M Masellis,M Masellis,M Masellis,Eliezer Masliah,Pamela J. McLean,Brit Mollenhauer,Brit Mollenhauer,Thomas J. Montine,Thomas J. Montine,Emilio Moreno,Emilio Moreno,Emilio Moreno,Etsuro Mori,Etsuro Mori,Etsuro Mori,Melissa E. Murray,John T. O'Brien,John T. O'Brien,Sotoshi Orimo,Sotoshi Orimo,Ronald B. Postuma,Ronald B. Postuma,Shankar Ramaswamy,Shankar Ramaswamy,Owen A. Ross,David P. Salmon,David P. Salmon,Andrew B. Singleton,Andrew B. Singleton,Angela Taylor,Angela Taylor,Alan Thomas,Pietro Tiraboschi,Jon B. Toledo,John Q. Trojanowski,Debby W. Tsuang,Zuzana Walker,Zuzana Walker,Masahito Yamada,Masahito Yamada,Kenji Kosaka +95 more
TL;DR: The Dementia with Lewy Bodies (DLB) Consortium has refined its recommendations about the clinical and pathologic diagnosis of DLB, updating the previous report, which has been in widespread use for the last decade.
Journal ArticleDOI
Detection of oligomeric forms of α-synuclein protein in human plasma as a potential biomarker for Parkinson’s disease
Omar M. A. El-Agnaf,Sultan A. Salem,Katerina E. Paleologou,Martin D. Curran,Mark J. Gibson,Jennifer A. Court,Jennifer A. Court,Michael G. Schlossmacher,Michael G. Schlossmacher,David Allsop +9 more
TL;DR: A novel ELISA method is developed that detects only oligomeric “soluble aggregates” of α‐syn in human plasma as a potential biomarker for Parkinson's disease and offers new opportunities for developing diagnostic tests for PD and related diseases.
Journal ArticleDOI
α-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma
Omar M. A. El-Agnaf,Sultan A. Salem,Katerina E. Paleologou,Leanne J. Cooper,Nigel J. Fullwood,Mark J. Gibson,Martin D. Curran,Jennifer A. Court,David M. A. Mann,Shu-ichi Ikeda,Mark R. Cookson,John Hardy,David Allsop +12 more
TL;DR: The findings suggest that cells normally secrete α‐syn into their surrounding media, both in vitro and in vivo, and the detection of extracellular α‐ syn and/or its modified forms in body fluids, particularly in human plasma, offers new opportunities for the development of diagnostic tests for PD.
Journal ArticleDOI
Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases.
TL;DR: This theme of protein aggregation as it relates to the two most common neurodegenerative conditions—Alzheimer's and Parkinson’s diseases is discussed.
Journal ArticleDOI
α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer.
Bruno Fauvet,Martial K. Mbefo,Mohamed Bilal Fares,Carole Desobry,Sarah Michael,Mustafa T. Ardah,Elpida Tsika,Philippe Coune,Michel Prudent,Niels Lion,David Eliezer,Darren J. Moore,Bernard L. Schneider,Patrick Aebischer,Omar M. A. El-Agnaf,Eliezer Masliah,Hilal A. Lashuel +16 more
TL;DR: Wang et al. as discussed by the authors investigated the oligomeric state of α-syn in mouse, rat, and human brains and showed that both human and rodent αsyn expressed in the central nervous system exist predominantly as an unfolded monomer.