Hodaka Yamakado

TL;DR: Results indicate that α-Syn PFF inoculation into the mouse gastrointestinal tract can induce α- synuclein pathology resembling that of very early PD, but other factors are apparently required if further progression of PD pathology is to be replicated in this animal model.

TL;DR: Ageing promoted conversion of both full-length and C-terminally truncated α-synuclein species into insolube and proteinase K-resistant fibres, with strongest accumulation in the striatum, resembling biochemical changes seen in human Parkinson's disease.

TL;DR: This study proposes TLR2 immunotherapy as a novel therapeutic strategy for synucleinopathies of the aging population and demonstrated that administration of anti-TLR2 alleviated α-synuclein accumulation in neuronal and astroglial cells, neuroinflammation, neurodegeneration, and behavioral deficits in an α- Synuclein tg mouse model of PD/DLB.

TL;DR: It is shown, using a pH-sensitive probe, that internalization of α-synuclein amyloid fibrils in neuroblastoma cells is dependent on heparan sulfate, whereasInternalization of smaller non-amyloid oligomers is not, and overall sulfation of the heparans sulfate chains is more important than sulfation at particular sites along the chains.

TL;DR: GBA-/- medaka is revealed as a novel neuronopathic GD model, the pahological mechanisms of α-syn accumulation caused by GCase deficiency, and the minimal contribution ofα-syn to the pathogenesis of neuronopathicGD are revealed.