M
Masashi Ikuno
Researcher at Kyoto University
Publications - 14
Citations - 184
Masashi Ikuno is an academic researcher from Kyoto University. The author has contributed to research in topics: Parkinson's disease & Medicine. The author has an hindex of 4, co-authored 10 publications receiving 82 citations.
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Journal ArticleDOI
α-Synuclein BAC transgenic mice exhibit RBD-like behaviour and hyposmia: a prodromal Parkinson’s disease model
Tomoyuki Taguchi,Masashi Ikuno,Mari Hondo,Laxmi Kumar Parajuli,Katsutoshi Taguchi,Jun Ueda,Masanori Sawamura,Shinya Okuda,Etsuro Nakanishi,Junko Hara,Norihito Uemura,Yusuke Hatanaka,Takashi Ayaki,Shuichi Matsuzawa,Masaki Tanaka,Omar M. A. El-Agnaf,Masato Koike,Masashi Yanagisawa,Maiko T. Uemura,Hodaka Yamakado,Ryosuke Takahashi +20 more
TL;DR: A novel mouse model of prodromal Parkinson's disease that showed RBD-like behaviour and hyposmia without motor symptoms is created and an expression pattern of human α-synuclein very similar to that of endogenous mouse α- synuclein is shown.
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GBA haploinsufficiency accelerates alpha-synuclein pathology with altered lipid metabolism in a prodromal model of Parkinson's disease.
Masashi Ikuno,Hodaka Yamakado,Hisako Akiyama,Laxmi Kumar Parajuli,Katsutoshi Taguchi,Junko Hara,Norihito Uemura,Yusuke Hatanaka,Katsumi Higaki,Kousaku Ohno,Masaki Tanaka,Masato Koike,Yoshio Hirabayashi,Ryosuke Takahashi +13 more
TL;DR: A novel prodromal mouse model is created to study the disease pathogenesis and develop novel therapeutics for PD and the mechanism by which heterozygous gba deficiency contributes to PD through abnormal lipid metabolism under conditions of an altered asyn expression in vivo is revealed.
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α-Synuclein Spread from Olfactory Bulb Causes Hyposmia, Anxiety, and Memory Loss in BAC-SNCA Mice.
Norihito Uemura,Norihito Uemura,Jun Ueda,Toru Yoshihara,Masashi Ikuno,Maiko T. Uemura,Maiko T. Uemura,Hodaka Yamakado,Masahide Asano,John Q. Trojanowski,Ryosuke Takahashi +10 more
TL;DR: In this paper, the authors examined the clinicopathological contribution of α-synuclein spread from the olfactory bulb to the lower brain stem and showed that α-Syn spread from olfia to the brain regions that are included in the limbic system and have connections with it, leading to the development of hyposmia, anxiety and memory loss.
Journal ArticleDOI
Animal Model for Prodromal Parkinson's Disease
TL;DR: This article reviews the animal models that exhibit NMS as prodromal symptoms of Parkinson’s disease and discusses an appropriate prodROMal model and its importance for the development of DMT of PD.
Journal ArticleDOI
Developmental changes in dendritic spine morphology in the striatum and their alteration in an A53T α-synuclein transgenic mouse model of Parkinson’s disease
Laxmi Kumar Parajuli,Ken Wako,Suiki Maruo,Soichiro Kakuta,Tomoyuki Taguchi,Masashi Ikuno,Hodaka Yamakado,Ryosuke Takahashi,Masato Koike +8 more
TL;DR: The data suggest that PD is accompanied by an abnormality in the mechanisms that control synapse growth and maturity, suggesting a homeostatic balance between spine head volume and spine density.