J
Junyu Wang
Researcher at Second Military Medical University
Publications - 28
Citations - 591
Junyu Wang is an academic researcher from Second Military Medical University. The author has contributed to research in topics: Glioma & Apoptosis. The author has an hindex of 12, co-authored 27 publications receiving 477 citations.
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Journal ArticleDOI
Long noncoding RNA-SRLR elicits intrinsic sorafenib resistance via evoking IL-6/STAT3 axis in renal cell carcinoma
Zhenyu Xu,Fu Yang,D Wei,Bing Liu,Cheng Chen,Yi Bao,Zhenjie Wu,Deng-Shuang Wu,H Tan,Juan Li,Junyu Wang,Liu Jiayi,Shuhan Sun,Le Qu,Le Qu,Linhui Wang +15 more
TL;DR: A long non-coding RNA referred to as lncRNA-SRLR (sorafenib resistance-associated lnc RNA in RCC) that is upregulated in intrinsically sorafenIB-resistant RCCs is identified and may serve as not only a predictive biomarker for inherent sorafinib resistance but also as a therapeutic target to enhance responses to sorAFenib in R CC patients.
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Knockdown of cyclin D1 inhibits proliferation, induces apoptosis, and attenuates the invasive capacity of human glioblastoma cells
Junyu Wang,Qi Wang,Yong Cui,Zhen Yang Liu,Wei Zhao,Chun Lin Wang,Yan Dong,Lijun Hou,Guohan Hu,Chun Luo,Juxiang Chen,Yicheng Lu +11 more
TL;DR: Overexpression of cyclin D1 enhanced the proliferation and invasive potential of human glioblastoma cells, while reducing apoptosis, and may provide a new gene therapy approach for patients with malignant glioma.
Journal ArticleDOI
Ubiquitin-specific protease 2a stabilizes MDM4 and facilitates the p53-mediated intrinsic apoptotic pathway in glioblastoma.
Chunlin Wang,Junyu Wang,Zhen-Yang Liu,Xiao-Mei Ma,Xiaowen Wang,Hai Jin,Xiao-Ping Zhang,Da Fu,Lijun Hou,Yicheng Lu +9 more
TL;DR: The results suggest that USP2a binds to and stabilizes MDM4; thus in turn, it enhances the mitochondrial localization of p53 and promotes apoptosis in glioma cells.
Journal ArticleDOI
RLIP76 is overexpressed in human glioblastomas and is required for proliferation, tumorigenesis and suppression of apoptosis.
Qi Wang,Junyu Wang,Xiao-Ping Zhang,Xiao-Ping Zhang,Zhongwei Lv,Da Fu,Yicheng Lu,Guohan Hu,Chun Luo,Juxiang Chen +9 more
TL;DR: It is found that the adenosine triphosphatase function of Rlip76 modulates Rac1 activity by regulating Rac1 protein ubiquitylation and degradation and that this activity promotes proliferation and suppresses glioma cell apoptosis through a mechanism independent of Rho-selective GTPase-activating protein.
Journal ArticleDOI
Retinoblastoma protein-interacting zinc-finger gene 1 (RIZ1) dysregulation in human malignant meningiomas.
Z Y Liu,Junyu Wang,Huimin Liu,X M Ma,Chunlin Wang,Xiao-Ping Zhang,Y Q Tao,Yicheng Lu,J C Liao,Guohan Hu +9 more
TL;DR: It is found for the first time that the expression of RIZ1 genes are associated with meningiomas progression through extensive analyses of Affymetrix GeneChip microarray data, and expression is significantly downregulated as the formation of mening iomas progressed.