J
Juan Li
Researcher at Peking Union Medical College
Publications - 153
Citations - 14388
Juan Li is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 30, co-authored 112 publications receiving 10646 citations. Previous affiliations of Juan Li include University of Western Ontario & Yunnan University.
Papers
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Journal ArticleDOI
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.
Roujian Lu,Xiang Zhao,Juan Li,Peihua Niu,Bo Yang,Honglong Wu,Wenling Wang,Hao Song,Baoying Huang,Na Zhu,Yuhai Bi,Xuejun Ma,Faxian Zhan,Liang Wang,Tao Hu,Hong Zhou,Zhenhong Hu,Weimin Zhou,Li Zhao,Jing Chen,Yao Meng,Ji Wang,Yang Lin,Jianying Yuan,Zhihao Xie,Jinmin Ma,William J. Liu,Dayan Wang,Wenbo Xu,Edward C. Holmes,George F. Gao,George F. Gao,Guizhen Wu,Weijun Chen,Weifeng Shi,Wenjie Tan,Wenjie Tan +36 more
TL;DR: The phylogenetic analysis suggests that bats might be the original host of this virus, an animal sold at the seafood market in Wuhan might represent an intermediate host facilitating the emergence of the virus in humans.
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Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin.
Peng Zhou,Hang Fan,Tian Lan,Xing-Lou Yang,Weifeng Shi,Wei Zhang,Yan Zhu,Ya-Wei Zhang,Qingmei Xie,Shailendra Mani,Xiao-Shuang Zheng,Bei Li,Jinman Li,Hua Guo,Guangqian Pei,Xiaoping An,Jun-Wei Chen,Ling Zhou,Kai-jie Mai,Zixian Wu,Di Li,Danielle E. Anderson,Libiao Zhang,Shi-Yue Li,Zhiqiang Mi,Tongtong He,Feng Cong,Pengju Guo,Ren Huang,Yun Luo,Xiang-Ling Liu,Jing Chen,Yong Huang,Qiang Sun,Xianglilan Zhang,Yuan-Yuan Wang,Shaozhen Xing,Yan-Shan Chen,Yuan Sun,Juan Li,Peter Daszak,Lin-Fa Wang,Zhengli Shi,Yigang Tong,Jingyun Ma +44 more
TL;DR: Analysis of viral samples from deceased piglets shows that a bat coronav virus was responsible for an outbreak of fatal disease in China and highlights the importance of the identification of coronavirus diversity and distribution in bats in order to mitigate future outbreaks of disease.
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A Novel Bat Coronavirus Closely Related to SARS-CoV-2 Contains Natural Insertions at the S1/S2 Cleavage Site of the Spike Protein.
Hong Zhou,Xing Chen,Tao Hu,Juan Li,Hao Song,Yanran Liu,Peihan Wang,Di Liu,Jing Yang,Edward C. Holmes,Alice C. Hughes,Yuhai Bi,Weifeng Shi +12 more
TL;DR: Critically, and in a similar manner to SARS-CoV-2, RmYN02 was characterized by the insertion of multiple amino acids at the junction site of the S1 and S2 subunits of the spike (S) protein, providing strong evidence that such insertion events can occur naturally in animal betacoronaviruses.
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Genomic and Proteomic Analyses of the Fungus Arthrobotrys oligospora Provide Insights into Nematode-Trap Formation
Jinkui Yang,Lei Wang,Xinglai Ji,Yun Feng,Xiaomin Li,Chenggang Zou,Jianping Xu,Yan Ren,Qili Mi,Junli Wu,Shuqun Liu,Yu Liu,Xiaowei Huang,Haiyan Wang,Xuemei Niu,Juan Li,Lianming Liang,Yanlu Luo,Kaifang Ji,Wei Zhou,Zefen Yu,Guo-Hong Li,Liu Yajun,Lei Li,Min Qiao,Lu Feng,Ke-Qin Zhang +26 more
TL;DR: This study will facilitate the identification of pathogenicity-related genes and provide a broad foundation for understanding the molecular and evolutionary mechanisms underlying fungi-nematodes interactions.
Journal ArticleDOI
Hemorrhagic Fever Caused by a Novel Bunyavirus in China: Pathogenesis and Correlates of Fatal Outcome
Yong-Zhen Zhang,Yong-Wen He,Yong-An Dai,Yanwen Xiong,Han Zheng,Dun-Jin Zhou,Juan Li,Qiangzheng Sun,Xuelian Luo,Yuli Cheng,Xin-Cheng Qin,Jun-Hua Tian,Xiao-Ping Chen,Bin Yu,Dong Jin,Wen-Ping Guo,Wei Li,Wen Wang,Jin-Song Peng,Guo-Bin Zhang,Shaomin Zhang,Xiao-Min Chen,Yan Wang,Ming-Hui Li,Zhenjun Li,Shan Lu,Changyun Ye,Menno D. de Jong,Jianguo Xu +28 more
TL;DR: Viral replication and host immune responses play an important role in determining the severity and clinical outcome in patients with infection by HYSV.