Jure Acimovic

TL;DR: Cyp51 knock-out mice provide evidence that Cyp51 is essential for embryogenesis and present a potential animal model for studying ABS syndrome in humans.

TL;DR: This manuscript shows that selection of reference gene (Actb) that is often used for analyses in individual mouse strains leads to errors if used for normalization when different mouse strains are compared, and identifies alternative reference genes that are stable in these comparisons.

TL;DR: This method is suitable for studies on the effect of different inhibitors and stimulators of cholesterol synthesis in cultured cells and is relevant also for clinical applications since abnormally increased late cholesterol intermediates in patients are representations of the inherited disorders linked to different enzyme defects in the post-squalene cholesterol biosynthesis.

TL;DR: All hitherto known structures of post-squalene steroidal triterpenes of cholesterol synthesis, their biological roles and the enzymes responsible for their synthesis are reviewed, and kinetic parameters of enzymes and sterol intermediate concentrations from various tissues are summarized.

TL;DR: In this article, the brain levels of HMG-CoA reductase mRNA and CoA synthase mRNA were increased in the brain of over-expressed human sterol 27-hydroxylase (CYP27A1).