K
Katalin Monostory
Researcher at Hungarian Academy of Sciences
Publications - 91
Citations - 1846
Katalin Monostory is an academic researcher from Hungarian Academy of Sciences. The author has contributed to research in topics: Cytochrome P450 & Pregnane X receptor. The author has an hindex of 22, co-authored 85 publications receiving 1634 citations.
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Journal ArticleDOI
Reduction of Toxic Metabolite Formation of Acetaminophen
TL;DR: Cimetidin is used in the therapy of acetaminophen overdose as an inhibitor of cytochrome P450, it is not able to reduce NAPQI formation, and selective CYP2E1 inhibitors that are used in human therapy were tested for their inhibitory effect on NAPZI formation.
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Hormonal regulation of CYP1A expression.
TL;DR: The current knowledge about the role of hormones and hormone receptors as well as other essential factors in the modulation of CYP1A expression is summarized.
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Perspectives of the non-statin hypolipidemic agents
Damjana Rozman,Katalin Monostory +1 more
TL;DR: This review focuses on the non-statin strategies for the treatment of hyperlipidemia in humans, and describes the characteristics of the later enzymes of cholesterol synthesis, starting from the squalene synthase step.
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Interspecies differences in acetaminophen sensitivity of human, rat, and mouse primary hepatocytes.
TL;DR: The toxicity induced by APAP overdose highly depends on the animal model applied, and no correlation was found between CYP2E1 activities and hepatocyte sensitivity of different species.
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Steroid regulation of drug-metabolizing cytochromes P450.
Katalin Monostory,Zdenek Dvorak +1 more
TL;DR: The purpose of this review is to highlight the interplay between drug-metabolizing P450s and steroid hormones as well as the interactions of xenosensor with steroid signaling pathways.