M
Martina Fink
Researcher at Ljubljana University Medical Centre
Publications - 22
Citations - 483
Martina Fink is an academic researcher from Ljubljana University Medical Centre. The author has contributed to research in topics: Sterol regulatory element-binding protein & Lanosterol. The author has an hindex of 9, co-authored 22 publications receiving 450 citations. Previous affiliations of Martina Fink include University of Ljubljana.
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Journal ArticleDOI
Many facets of mammalian lanosterol 14α-demethylase from the evolutionarily conserved cytochrome P450 family CYP51
TL;DR: While sterol regulatory element binding protein (SREBP)-dependent transcriptional regulation of CYP51 contributes to synthesis of cholesterol, the germ-cell-specific cAMP/CREMtau-dependent upregulation might contribute to increased production of MAS.
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Determination of reference genes for circadian studies in different tissues and mouse strains
Rok Košir,Jure Acimovic,Marko Goličnik,Martina Perše,Gregor Majdic,Martina Fink,Damjana Rozman +6 more
TL;DR: This manuscript shows that selection of reference gene (Actb) that is often used for analyses in individual mouse strains leads to errors if used for normalization when different mouse strains are compared, and identifies alternative reference genes that are stable in these comparisons.
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Cyclic Adenosine 3′,5′-Monophosphate(cAMP)/cAMP-Responsive Element Modulator (CREM)-Dependent Regulation of Cholesterogenic Lanosterol 14α-Demethylase (CYP51) in Spermatids
TL;DR: The mRNA levels of squalene synthase (an enzyme preceding CYP51 in cholesterol biosynthesis in testis of CREM-/- mice are unchanged as compared with wild-type animals, showing that regulation by CREMtau is not characteristic for all cholesterogenic genes expressed during spermatogenesis.
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A cAMP-Responsive Element Binding Site Is Essential for Sterol Regulation of the Human Lanosterol 14α-Demethylase Gene (CYP51)
TL;DR: This is the first gene in which cooperation between SREBP and a CREB/CRE modulator/activating transcription factor family transcription factor is shown to be essential and sufficient for SRE BP-dependent activation.
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Novel Insights into the Downstream Pathways and Targets Controlled by Transcription Factors CREM in the Testis
Rok Košir,Peter Juvan,Martina Perše,Tomaz Büdefeld,Gregor Majdic,Gregor Majdic,Martina Fink,Paolo Sassone-Corsi,Damjana Rozman +8 more
TL;DR: The study showed that the absence of Crem plays a more important role on different aspects of spermatogenesis as estimated previously, with its impact ranging from apoptosis induction to deregulation of major circadian clock genes, steroidogenesis and the cell-cell junction dynamics.