Justin Guinney

TL;DR: In this paper , a real-world outcome analysis of a distinct genomically defined underrepresented population was performed using Kaplan-Meier methods, and the authors found that advanced gastric and GEJ patients with HER2-low expression identified by IHC and RNA expression have a poor prognosis with shortest survival.

TL;DR: A new machine learning tool to identify unsupervised clinically-relevant (functional) subtypes and biomarkers by simultaneously integrating clinical phenotypes and single omics data, mainly, transcriptome is reported.

TL;DR: In this paper , associations of colorectal cancer tumor molecular profiles with genetic ancestry were examined, and the association of genetic ancestry proportions and genetic ancestry-imputed race and ethnicity categories with somatic mutations in relevant CRC genes and in expression profiles, including consensus molecular subtypes (CMS).

TL;DR: In this article , the authors used 654 ancestry-informative markers to estimate continental ancestry likelihoods for five regions: Africa (AFR), Americas (AMR), East Asia (EAS), Europe (EUR), and South Asia (SAS).

TL;DR: In the largest study of its kind, it is shown that dual tumor tissue and ctDNA testing—with samples collected either concurrently or longitudinally—identified more patients with actionable alterations than single modality testing alone and therefore should be considered as part of routine NGS testing.