D
Dan Theodorescu
Researcher at University of Colorado Boulder
Publications - 331
Citations - 22549
Dan Theodorescu is an academic researcher from University of Colorado Boulder. The author has contributed to research in topics: Bladder cancer & Cancer. The author has an hindex of 74, co-authored 303 publications receiving 20119 citations. Previous affiliations of Dan Theodorescu include Department of Urology, University of Virginia & Duke University.
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Journal ArticleDOI
Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies
Chetan Bettegowda,Chetan Bettegowda,Mark Sausen,Rebecca J. Leary,Isaac Kinde,Yuxuan Wang,Nishant Agrawal,Nishant Agrawal,Bjarne Bartlett,Bjarne Bartlett,Hao Wang,Brandon Luber,Rhoda M. Alani,Emmanuel S. Antonarakis,Nilofer S. Azad,Alberto Bardelli,Henry Brem,John L. Cameron,Clarence Lee,Leslie A. Fecher,Leslie A. Fecher,Gary L. Gallia,Peter Gibbs,Dung T. Le,Dung T. Le,Robert L. Giuntoli,Michael Goggins,Michael D. Hogarty,Matthias Holdhoff,Seung-Mo Hong,Seung-Mo Hong,Yuchen Jiao,Hartmut Juhl,Jenny J. Kim,Giulia Siravegna,Daniel A. Laheru,Calogero Lauricella,Michael Lim,Evan J. Lipson,Suely Kazue Nagahashi Marie,George J. Netto,Kelly S. Oliner,Alessandro Olivi,Louise Olsson,Gregory J. Riggins,Andrea Sartore-Bianchi,Kerstin Schmidt,le-Ming Shih,Sueli Mieko Oba-Shinjo,Salvatore Siena,Dan Theodorescu,Jeanne Tie,Timothy T. Harkins,Silvio Veronese,Tian Li Wang,Jon D. Weingart,Christopher L. Wolfgang,Laura D. Wood,Dongmei Xing,Ralph H. Hruban,Jian Wu,Peter J. Allen,C. Max Schmidt,Michael A. Choti,Victor E. Velculescu,Kenneth W. Kinzler,Bert Vogelstein,Nickolas Papadopoulos,Luis A. Diaz,Luis A. Diaz +69 more
TL;DR: The ability of circulating tumor DNA (ctDNA) to detect tumors in 640 patients with various cancer types was evaluated and suggested that ctDNA is a broadly applicable, sensitive, and specific biomarker that can be used for a variety of clinical and research purposes.
Journal ArticleDOI
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
Patrick J. Killela,Zachary J. Reitman,Yuchen Jiao,Chetan Bettegowda,Nishant Agrawal,Luis A. Diaz,Allan H. Friedman,Henry S. Friedman,Gary L. Gallia,Beppino C. Giovanella,Arthur P. Grollman,Tong-Chuan He,Yiping He,Ralph H. Hruban,George I. Jallo,Nils Mandahl,Alan K. Meeker,Fredrik Mertens,George J. Netto,B.K. Ahmed Rasheed,Gregory J. Riggins,Thomas A. Rosenquist,Mark Schiffman,Ie Ming Shih,Dan Theodorescu,Michael Torbenson,Victor E. Velculescu,Tian Li Wang,Nicolas Wentzensen,Laura D. Wood,Ming Zhang,Roger E. McLendon,Darell D. Bigner,Kenneth W. Kinzler,Bert Vogelstein,Nickolas Papadopoulos,Hai Yan +36 more
TL;DR: TERT and ATRX mutations were mutually exclusive, suggesting that these two genetic mechanisms confer equivalent selective growth advantages and provide a biomarker that may be useful for the early detection of urinary tract and liver tumors and aid in the classification and prognostication of brain tumors.
Journal ArticleDOI
Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder
Yaoting Gui,Guangwu Guo,Yi Huang,Xueda Hu,Aifa Tang,Aifa Tang,Shengjie Gao,Renhua Wu,Chao Chen,Xianxin Li,Liang Zhou,Minghui He,Zesong Li,Zesong Li,Xiaojuan Sun,Wenlong Jia,Jinnong Chen,Shangming Yang,Fangjian Zhou,Xiaokun Zhao,Shengqing Wan,Rui Ye,Chaozhao Liang,Zhisheng Liu,Peide Huang,Chunxiao Liu,Hui Jiang,Yong Wang,Hancheng Zheng,Liang Sun,Xingwang Liu,Zhimao Jiang,Dafei Feng,Jing Chen,Song Wu,Jing Zou,Zhongfu Zhang,Ruilin Yang,Jun Zhao,Congjie Xu,Weihua Yin,Zhichen Guan,Jiongxian Ye,Hong Zhang,Jingxiang Li,Karsten Kristiansen,Michael L. Nickerson,Dan Theodorescu,Yingrui Li,Xiuqing Zhang,Songgang Li,Jian Wang,Huanming Yang,Jun Wang,Zhiming Cai,Zhiming Cai +55 more
TL;DR: The results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.
Journal ArticleDOI
Tert promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
Hai Yan,Patrick J. Killela,Zachary J. Reitman,Yuchen Jiao,Chetan Bettegowda,Nishant Agrawal,Luis A. Diaz,Allan H. Friedman,Henry S. Friedman,G.L. Gallia,B.C. Giovanella,Arthur P. Grollman,Tong-Chuan He,Yiping He,R.H. Hruban,G.I. Jallo,Nils Mandahl,Alan K. Meeker,Fredrik Mertens,George J. Netto,B.A. Rasheed,Gregory J. Riggins,T.A. Rosenquist,M. Schiffman,IeM Shih,Dan Theodorescu,M.S. Torbenson,Victor E. Velculescu,Tian Li Wang,N. Wentzensen,Laura D. Wood,Ming Zhang,Patrick Healy,Rui Yang,Bill H. Diplas,Zhaohui Wang,Paula K. Greer,Huishan Zhu,Catherine Y. Wang,Austin B. Carpenter,James E. Herndon,Roger E. McLendon,Kenneth W. Kinzler,Bert Vogelstein,N. Papadopoulos,Darell D. Bigner +45 more
TL;DR: TERT and ATRX mutations suggest that these two genetic mechanisms confer equivalent selective growth advantages and provide a biomarker that may be useful for the early detection of urinary tract and liver tumors and aid in the classification and prognostication of brain tumors.
Journal ArticleDOI
Naturally Occurring Human Urinary Peptides for Use in Diagnosis of Chronic Kidney Disease
David M. Good,Petra Zürbig,Àngel Argilés,Hartwig W. Bauer,Georg M. N. Behrens,Joshua J. Coon,Mohammed Dakna,Stéphane Decramer,Christian Delles,Anna F. Dominiczak,Jochen H. H. Ehrich,Frank Eitner,Danilo Fliser,Moritz Frommberger,Arnold Ganser,Mark Girolami,Igor Golovko,Wilfried Gwinner,Marion Haubitz,Stefan Herget-Rosenthal,Joachim Jankowski,Holger Jahn,George Jerums,Bruce A. Julian,Markus Kellmann,Volker Kliem,Walter Kolch,Andrzej S. Krolewski,Andrzej S. Krolewski,Mario Luppi,Ziad A. Massy,Michael Melter,Christian Neusüss,Jan Novak,Karlheinz Peter,Kasper Rossing,Harald D. Rupprecht,Joost P. Schanstra,Eric Schiffer,Jens-Uwe Stolzenburg,Lise Tarnow,Dan Theodorescu,Visith Thongboonkerd,Raymond Vanholder,Eva M. Weissinger,Harald Mischak,Philippe Schmitt-Kopplin +46 more
TL;DR: The establishment of a reproducible, high resolution method for peptidome analysis of naturally occurring human urinary peptides and proteins, ranging from 800 to 17,000 Da, using samples from 3,600 individuals analyzed by capillary electrophoresis coupled to MS is reported.