J
Justin Guinney
Researcher at Sage Bionetworks
Publications - 129
Citations - 21754
Justin Guinney is an academic researcher from Sage Bionetworks. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 32, co-authored 97 publications receiving 12819 citations. Previous affiliations of Justin Guinney include Duke University & University of Washington.
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Molecular response in newly diagnosed chronic-phase chronic myeloid leukemia: prediction modeling and pathway analysis
Jerald P. Radich,Matthew A. Wall,Susan Branford,Catarina D. Campbell,Shalini Chaturvedi,Daniel J. DeAngelo,Michael M.N. Deininger,Justin Guinney,Andreas Hochhaus,Timothy P. Hughes,Hagop M. Kantarjian,Richard A. Larson,Sai Li,Rodrigo O. Maegawa,Kaushal Mishra,Vanessa Obourn,Javier Pinilla-Ibarz,Das Purkayastha,Islam Sadek,Giuseppe Saglio,Alok Shrestha,Brian S. White,Brian J. Druker +22 more
TL;DR: In this article , gene expression in whole blood samples from 112 patients from a large phase III randomized trial (clinicaltrials gov. Identifier: NCT00471497), dichotomizing cases into good responders (BCR::ABL1 ≤10% on the International Scale by 3 and 6 months and ≤0.1% by 12 months) and poor responders (failure to meet these criteria).
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USP10 regulates ZEB1 ubiquitination and protein stability to inhibit ZEB1-mediated colorectal cancer metastasis.
TL;DR: In this paper , MeK-ERK-regulated interaction of USP10 with ZEB1 with deubiquitinase ubiquitin-specific protease 10 (USP10) was found to promote the proteasomal degradation and suppress its demonstrated ability to mediate tumor metastasis.
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Machine learning in rare disease
Jineta Banerjee,Jaclyn N. Taroni,Robert J. Allaway,Deepashree Venkatesh Prasad,Justin Guinney,Casey S. Greene +5 more
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Reply to the letter to the editor ‘Including lynch syndrome in personalized prognostication and follow-up of stage II and III colon cancer’ by Sciallero et al.
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Risk of severe acute respiratory syndrome coronavirus 2 infection among women with polycystic ovary syndrome
Snigdha Alur-Gupta,Mary Regina Boland,Anuja Dokras,Melissa A. Haendel,Christopher G. Chute,Anita Walden,Kenneth Gersing,Leonie Misquitta,Penny W. Burgoon,Samuel A. Bozzette,Mariam Deacy,Christopher Dillon,Rebecca A. Erwin-Cohen,Nicole Garbarini,Valery M. Gordon,Michael G. Kurilla,Emily Marti,Simon Michael,Liliana Margarita Portilla,Clare Bracewell Schmitt,Meredith Temple-O’Connor,Tellen D. Bennett,David Eichmann,Justin Guinney,Warren A. Kibbe,Hongfang Liu,Philip R. O. Payne,Emily R. Pfaff,Peter N. Robinson,Joel H. Saltz,Heidi Spratt,Justin B. Starren,Christine Suver,A. Wilcox,Andrew E. Williams,Chunlei Wu,Davera Gabriel,Stephanie S Hong,Kristin Kostka,Harold Lehmann,Richard A. Moffitt,Michele I. Morris,Matvey B. Palchuk,Xiaohan Tanner Zhang,Richard L Zhu,Marshall Clark,Andrew T. Girvin,Adam M Lee,Robert T. Miller,Kellie M Walters,Will Cooper,Patricia A Francis,Rafael Fuentes,Alexis Graves,Julie A. McMurry,Andrew J. Neumann,Shawn T. O’Neil,Usman Khalid Sheikh,Elizabeth Zampino,Mark Bissell,Katie Bradwell,Amin Manna,N. A. Qureshi,Mary M. Saltz,Carolyn T. Bramante,Jeremy Harper,Wenndy Hernandez,Farrukh M. Koraishy,Federico C. Mariona,Amitav Saha,S. Swaroop Vedula +70 more
TL;DR: In this paper , women with polycystic ovary syndrome (PCOS) had a higher incidence of testing positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) than those without PCOS and evaluate whether PCOS diagnosis independently increased the risk of moderate or severe disease in those with positive SARS-coV2 test results.