M
Matthew MacKay
Researcher at Cornell University
Publications - 44
Citations - 3096
Matthew MacKay is an academic researcher from Cornell University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 16, co-authored 32 publications receiving 1563 citations. Previous affiliations of Matthew MacKay include Becton Dickinson.
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Journal ArticleDOI
The N 6 -methyladenosine (m 6 A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells
Ly P. Vu,Brian F. Pickering,Yuanming Cheng,Sara Zaccara,Diu T.T. Nguyen,Gerard Minuesa,Timothy Chou,Arthur Chow,Yogesh Saletore,Matthew MacKay,Jessica Schulman,Christopher Famulare,Minal Patel,Virginia M. Klimek,Francine E. Garrett-Bakelman,Ari Melnick,Martin Carroll,Christopher E. Mason,Samie R. Jaffrey,Michael G. Kharas +19 more
TL;DR: It is shown that shRNA-mediated depletion of the m6A-forming enzyme METTL3 in human hematopoietic stem/progenitor cells (HSPCs) promotes cell differentiation, coupled with reduced cell proliferation, and this results provide a rationale for the therapeutic targeting of MET TL3 in myeloid leukemia.
Journal ArticleDOI
The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight.
Francine E. Garrett-Bakelman,Francine E. Garrett-Bakelman,Manjula Darshi,Stefan J. Green,Ruben C. Gur,Ling Lin,Brandon R. Macias,Miles J. McKenna,Cem Meydan,Tejaswini Mishra,Jad Nasrini,Brian D. Piening,Brian D. Piening,Lindsay F. Rizzardi,Kumar Sharma,Jamila H. Siamwala,Jamila H. Siamwala,Lynn Taylor,Martha Hotz Vitaterna,Maryam Afkarian,Ebrahim Afshinnekoo,Sara Ahadi,Aditya Ambati,Maneesh Arya,Daniela Bezdan,Colin M. Callahan,Songjie Chen,Augustine M.K. Choi,George E. Chlipala,Kévin Contrepois,Marisa Covington,Brian Crucian,Immaculata De Vivo,David F. Dinges,Douglas J. Ebert,Jason I. Feinberg,Jorge Gandara,Kerry George,John Goutsias,George Grills,Alan R. Hargens,Martina Heer,Martina Heer,Ryan P. Hillary,Andrew N. Hoofnagle,Vivian Hook,Garrett Jenkinson,Garrett Jenkinson,Peng Jiang,Ali Keshavarzian,Steven S. Laurie,Brittany Lee-McMullen,Sarah B. Lumpkins,Matthew MacKay,Mark Maienschein-Cline,Ari Melnick,Tyler M. Moore,Kiichi Nakahira,Hemal H. Patel,Robert Pietrzyk,Varsha Rao,Rintaro Saito,Rintaro Saito,Denis Salins,Jan M. Schilling,Dorothy D. Sears,Caroline Sheridan,Michael B. Stenger,Rakel Tryggvadottir,Alexander E. Urban,Tomas Vaisar,Benjamin Van Espen,Jing Zhang,Michael G. Ziegler,Sara R. Zwart,John B. Charles,Craig E. Kundrot,Graham B. I. Scott,Susan M. Bailey,Mathias Basner,Andrew P. Feinberg,Stuart M. C. Lee,Christopher E. Mason,Emmanuel Mignot,Brinda K. Rana,Scott M. Smith,Michael Snyder,Fred W. Turek,Fred W. Turek +88 more
TL;DR: Given that the majority of the biological and human health variables remained stable, or returned to baseline, after a 340-day space mission, these data suggest that human health can be mostly sustained over this duration of spaceflight.
Journal ArticleDOI
Multiplex qPCR discriminates variants of concern to enhance global surveillance of SARS-CoV-2.
Chantal B.F. Vogels,Mallery I. Breban,Isabel M. Ott,Tara Alpert,Mary E. Petrone,Anne E. Watkins,Chaney C. Kalinich,Rebecca Earnest,Jessica E. Rothman,Jaqueline Goes de Jesus,Ingra Morales Claro,Giulia M. Ferreira,Giulia M. Ferreira,Myuki A E Crispim,Lavanya Singh,Houriiyah Tegally,Ugochukwu J. Anyaneji,Emma B. Hodcroft,Christopher E. Mason,Gaurav Khullar,Jessica Metti,Joel T. Dudley,Matthew MacKay,Megan Nash,Jianhui Wang,Chen Liu,Pei Hui,Steven Murphy,Caleb Neal,Eva Laszlo,Marie L. Landry,Anthony Muyombwe,Randy Downing,Jafar Razeq,Tulio de Oliveira,Nuno R. Faria,Nuno R. Faria,Nuno R. Faria,Ester Cerdeira Sabino,Richard A. Neher,Joseph R. Fauver,Nathan D. Grubaugh +41 more
TL;DR: In this paper, the authors designed and validated an open-source PCR assay to detect SARS-CoV-2 VOC using ORF1a Δ3675-3677 as the primary target and spike Δ69-70 to differentiate.
Journal ArticleDOI
Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact.
Willian A. da Silveira,Hossein Fazelinia,Sara Brin Rosenthal,Evagelia C. Laiakis,Man S. Kim,Cem Meydan,Yared H. Kidane,Komal S. Rathi,Scott M. Smith,Benjamin Stear,Yue Ying,Yuanchao Zhang,Jonathan Foox,Susana Zanello,Brian Crucian,Dong Wang,Adrienne Nugent,Helio A. Costa,Sara R. Zwart,Sonja Schrepfer,R. A. Leo Elworth,Nicolae Sapoval,Todd J. Treangen,Matthew MacKay,Nandan S. Gokhale,Stacy M. Horner,Larry N. Singh,Douglas C. Wallace,Douglas C. Wallace,Jeffrey S. Willey,Jonathan C. Schisler,Robert Meller,J. Tyson McDonald,Kathleen M. Fisch,Gary Hardiman,Gary Hardiman,Deanne Taylor,Deanne Taylor,Christopher E. Mason,Sylvain V. Costes,Afshin Beheshti +40 more
TL;DR: Overall pathway analyses on the multi-omics datasets showed significant enrichment for mitochondrial processes, as well as innate immunity, chronic inflammation, cell cycle, circadian rhythm, and olfactory functions, indicating mitochondrial stress as a consistent phenotype of spaceflight.
Journal ArticleDOI
Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep-Space Exploration.
Ebrahim Afshinnekoo,Ryan T. Scott,Matthew MacKay,Eloise Pariset,Eloise Pariset,Egle Cekanaviciute,Richard Barker,Simon Gilroy,Duane C. Hassane,Scott M. Smith,Sara R. Zwart,Mayra Nelman-Gonzalez,Brian Crucian,S. A. Ponomarev,Oleg Orlov,Dai Shiba,Masafumi Muratani,Masayuki Yamamoto,Stephanie E. Richards,Parag Vaishampayan,Cem Meydan,Jonathan Foox,Jacqueline Myrrhe,Eric Istasse,Nitin Kumar Singh,Kasthuri Venkateswaran,Jessica A. Keune,Hami E. Ray,Mathias Basner,Jack M. Miller,Jack M. Miller,Martha Hotz Vitaterna,Deanne Taylor,Deanne Taylor,Douglas C. Wallace,Douglas C. Wallace,Kathleen Rubins,Susan M. Bailey,Peter Grabham,Sylvain V. Costes,Christopher E. Mason,Afshin Beheshti,Afshin Beheshti +42 more
TL;DR: The known hazards of human spaceflight are reviewed, how spaceflight affects living systems through these six fundamental features, and the associated health risks of space exploration are discussed.