J
Justina Šileikytė
Researcher at Oregon Health & Science University
Publications - 15
Citations - 776
Justina Šileikytė is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Mitochondrial permeability transition pore & Mitochondrial membrane transport protein. The author has an hindex of 11, co-authored 15 publications receiving 672 citations. Previous affiliations of Justina Šileikytė include University of Padua.
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Journal ArticleDOI
Regulation of the mitochondrial permeability transition pore by the outer membrane does not involve the peripheral benzodiazepine receptor (Translocator Protein of 18 kDa (TSPO)).
Justina Šileikytė,Elizabeth Blachly-Dyson,Randall Sewell,Andrea Carpi,Roberta Menabò,Fabio Di Lisa,Fernanda Ricchelli,Paolo Bernardi,Michael Forte +8 more
TL;DR: The role of TSPO is critically assessed through the generation of mice in which the Tspo gene has been conditionally eliminated, showing that it plays no role in the regulation or structure of the PTP, and hearts lacking TSPo are as sensitive to ischemia-reperfusion injury as hearts from control mice.
Journal ArticleDOI
Channel formation by yeast F-ATP synthase and the role of dimerization in the mitochondrial permeability transition
Michela Carraro,Valentina Giorgio,Justina Šileikytė,Geppo Sartori,Michael Forte,Giovanna Lippe,Mario Zoratti,Ildikò Szabò,Paolo Bernardi +8 more
TL;DR: The results show that the yeast PTP originates from F-ATP synthase and indicate that dimerization is required for pore formation in situ, indicating that Ca2+-dependent channel formation is a conserved feature of F- ATP synthases.
Journal ArticleDOI
Regulation of the Inner Membrane Mitochondrial Permeability Transition by the Outer Membrane Translocator Protein (Peripheral Benzodiazepine Receptor)
Justina Šileikytė,Valeria Petronilli,Alessandra Zulian,Federica Dabbeni-Sala,Giuseppe Tognon,Peter Nikolov,Paolo Bernardi,Fernanda Ricchelli +7 more
TL;DR: The permeability transition is an inner membrane event that is regulated by the outer membrane through specific interactions with TSPO, formerly known as the peripheral benzodiazepine receptor.
Journal ArticleDOI
Shedding light on the mitochondrial permeability transition
TL;DR: These experiments provided remarkable information on the role, interactions and topology of His and Cys residues in permeability transition pore modulation and defined an important role for the outer membrane 18kDa translocator protein (formerly known as the peripheral benzodiazepine receptor) in regulation of the permeability Transition pore.
Journal ArticleDOI
The Mitochondrial Permeability Transition in Mitochondrial Disorders
Justina Šileikytė,Michael Forte +1 more
TL;DR: Recent advances made in elucidating the molecular nature of the PTP are summarized focusing on evidence pointing to mitochondrial FoF1-ATP synthase, studies aimed at discovering novel PTP inhibitors are summarized, and data supporting compromised PTP activity in specific mitochondrial diseases is reviewed.