K
K. Benjamin Garbutcheon-Singh
Researcher at University of Western Sydney
Publications - 11
Citations - 543
K. Benjamin Garbutcheon-Singh is an academic researcher from University of Western Sydney. The author has contributed to research in topics: Carboplatin & Cisplatin. The author has an hindex of 7, co-authored 11 publications receiving 483 citations. Previous affiliations of K. Benjamin Garbutcheon-Singh include University of Sydney & Health Science University.
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Journal ArticleDOI
Advances in Platinum Chemotherapeutics
Benjamin W. J. Harper,Anwen M. Krause-Heuer,Maxine P. Grant,Madhura Manohar,K. Benjamin Garbutcheon-Singh,Janice R. Aldrich-Wright +5 more
TL;DR: Recent advances in the field of platinum chemotherapeutics are highlighted, with a focus on the technologies that attempt to utilise the cytotoxic nature of cisplatin, whilst improving drug targeting to reduce side-effects.
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Transition Metal Based Anticancer Drugs
K. Benjamin Garbutcheon-Singh,Maxine P. Grant,Benjamin W. J. Harper,Anwen M. Krause-Heuer,Madhura Manohar,Nikita Orkey,Janice R. Aldrich-Wright +6 more
TL;DR: Metal complexes with activity are highlighted and the different approaches to the design of anticancer complexes are illustrated to show the need for new compounds with different mechanisms of action and resistance profiles.
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Cytotoxic platinum(II) intercalators that incorporate 1R,2R-diaminocyclopentane
TL;DR: The R,R enantiomer of 1,2-diaminocyclopentane (RRDACP) produced the most cytotoxic metallointercalators while 56MERRDACP and 47 MERRDACP with IC(50) values of 0.16 and 0.17 μM, respectively, in comparison to cisplatin (1 μM).
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Platinum Intercalators of DNA as Anticancer Agents
TL;DR: 1,10-phenanthroline-based complexes of the type [Pt(PL)(AL)]2+ (where PL is a polyaromatic ligand and AL is an ancillary ligand), including their cytotoxicity, DNA-binding behaviour and biological activity in vitro and in vivo are discussed.
Journal ArticleDOI
The effects of 56MESS on mitochondrial and cytoskeletal proteins and the cell cycle in MDCK cells
K. Benjamin Garbutcheon-Singh,Simon J. Myers,Benjamin W. J. Harper,Neville S. Ng,Qihan Dong,Chanlu Xie,Janice R. Aldrich-Wright +6 more
TL;DR: Results suggest that 56MESS is capable of causing cell-cycle arrest, and that mitochondrial and cell cycle proteins may be involved in the mode of action of cytotoxicity of 56MES.