K
K Brookes
Researcher at Medical Research Council
Publications - 10
Citations - 554
K Brookes is an academic researcher from Medical Research Council. The author has contributed to research in topics: Attention deficit hyperactivity disorder & Serotonin transporter. The author has an hindex of 6, co-authored 10 publications receiving 536 citations.
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Journal ArticleDOI
A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy.
K Brookes,Jon Mill,Camilla Guindalini,Sarah Curran,Xiaohui Xu,Jo Knight,Chih-Ken Chen,Yu-Shu Huang,Vaheshta Sethna,Eric Taylor,Wai Chen,Gerome Breen,Philip Asherson +12 more
TL;DR: A novel association was identified between ADHD, the intron 8 polymorphism, and a specific risk haplotype in both English and Taiwanese samples, and interaction between DAT1 genotypes and maternal use of alcohol during pregnancy suggests that Dat1 moderates the environmental risk and has implications for the prevention of ADHD.
Journal ArticleDOI
Association of fatty acid desaturase genes with attention-deficit/hyperactivity disorder.
TL;DR: The preliminary findings are suggestive of an association between FADS2 and ADHD, a significant association of ADHD with SNP rs498793 in the fatty acid desaturase 2 gene.
Journal ArticleDOI
The dopamine receptor D4 7-repeat allele and prenatal smoking in ADHD-affected children and their unaffected siblings: no gene-environment interaction.
Marieke E. Altink,Alejandro Arias-Vasquez,Alejandro Arias-Vasquez,Barbara Franke,Barbara Franke,Dorine Slaats-Willemse,Cathelijne J. M. Buschgens,Nanda Rommelse,Ellen A. Fliers,Richard Anney,K Brookes,Wai Chen,Michael Gill,Aisling Mulligan,Edmund J.S. Sonuga-Barke,Margaret Thompson,Joseph A. Sergeant,Stephen V. Faraone,Philip Asherson,Jan K. Buitelaar +19 more
TL;DR: Examination of the gene by environment (GxE) interaction of the DRD4 7-repeat allele and smoking during pregnancy on ADHD and oppositional behavior in families from the International Multicenter ADHD Genetics project found no GxE interactions.
Journal ArticleDOI
No evidence for the association of DRD4 with ADHD in a Taiwanese population within-family study
TL;DR: Investigating two markers within the DRD4 gene in a Taiwanese population, the exon 3 variable number tandem repeat (VNTR) and a 5' 120 base-pair duplication, found no evidence of association of ADHD with either polymorphism in this population was observed.
Journal ArticleDOI
Intelligence in DSM-IV combined type attention-deficit/hyperactivity disorder is not predicted by either dopamine receptor/transporter genes or other previously identified risk alleles for attention-deficit/hyperactivity disorder
Edmund J.S. Sonuga-Barke,K Brookes,Jan K. Buitelaar,Richard Anney,Paraskevi Bitsakou,Dieter Baeyens,Cathelijne J. M. Buschgens,Wai Chen,Hanna Christiansen,Jacques Eisenberg,Jonna Kuntsi,Iris Manor,Amanda Meliá,Aisling Mulligan,Nanda Rommelse,Ueli C Müller,Henrik Uebel,Tobias Banaschewski,Richard P. Ebstein,Barbara Franke,Michael Gill,Ana Miranda,Robert D. Oades,Herbert Roeyers,Aribert Rothenberger,Joseph Sergeant,Hans-Christoph Steinhausen,Margaret Thompson,Eric Taylor,Philip Asherson,Stephen V. Faraone +30 more
TL;DR: This large scale study with a clinically ascertained and regorously diagnosed sample failed to replicate the association between genetic polymorphisms in the dopamine system and IQ in ADHD.