A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy.
K Brookes,Jon Mill,Camilla Guindalini,Sarah Curran,Xiaohui Xu,Jo Knight,Chih-Ken Chen,Yu-Shu Huang,Vaheshta Sethna,Eric Taylor,Wai Chen,Gerome Breen,Philip Asherson +12 more
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TLDR
A novel association was identified between ADHD, the intron 8 polymorphism, and a specific risk haplotype in both English and Taiwanese samples, and interaction between DAT1 genotypes and maternal use of alcohol during pregnancy suggests that Dat1 moderates the environmental risk and has implications for the prevention of ADHD.Abstract:
Context:Attention-deficit/hyperactivitydisorder(ADHD) is a common heritable childhood behavioral disorder. Identifying risk factors for ADHD may lead to improved intervention and prevention. The dopamine transporter gene (DAT1) is associated with ADHD in several studies, with an average 1.2 odds ratio and evidence of heterogeneity across data sets. Objective: To investigate sources of heterogeneity by refining the DAT1 association using additional markers and investigating gene-environment interaction betweenDAT1andmaternaluseofalcoholandtobaccoduring pregnancy. Design: Prospective study. Setting and Patients:Children with ADHD from child behavior clinics in the southeast of England and in the Taipei area of Taiwan.read more
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Journal ArticleDOI
Molecular Genetics of Attention-Deficit/Hyperactivity Disorder
Stephen V. Faraone,Roy H. Perlis,Alysa E. Doyle,Jordan W. Smoller,Jennifer J. Goralnick,Meredith A. Holmgren,Pamela Sklar +6 more
TL;DR: Family, twin, and adoption studies provide compelling evidence that genes play a strong role in mediating susceptibility to ADHD, and seven genes for which the same variant has been studied in three or more case-control or family-based studies show statistically significant evidence of association with ADHD.
Journal ArticleDOI
Gene–environment interactions in psychiatry: joining forces with neuroscience
TL;DR: Opportunities and challenges in the collaboration between psychiatry, epidemiology and neuroscience in studying gene–environment interactions in psychiatry are discussed.
Journal ArticleDOI
Molecular genetics of attention deficit hyperactivity disorder.
Stephen V. Faraone,Eric Mick +1 more
TL;DR: Although twin studies demonstrate that ADHD is a highly heritable condition, molecular genetic studies suggest that the genetic architecture of ADHD is complex as discussed by the authors, and the handful of genomewide linkage and association scans that have been conducted thus far show divergent findings and are therefore not conclusive.
Journal ArticleDOI
Candidate gene studies of ADHD: a meta-analytic review.
TL;DR: A comprehensive meta-analytic review of the literature to determine which candidate genes show consistent evidence of association with childhood ADHD across studies found significant associations for several candidate genes including DAT1, DRD4,DRD5, 5HTT, HTR1B, and SNAP25.
Journal ArticleDOI
Attention-deficit-hyperactivity disorder: an update.
TL;DR: This patient population can be treated effectively with individualized treatment regimens of stimulants, atomoxetine, or bupropion, along with close monitoring, and longacting formulations (administered once/day) may improve adherence.
References
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Journal ArticleDOI
Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): Initial Reliability and Validity Data
Joan Kaufman,Boris Birmaher,David A. Brent,Uma Rao,Uma Rao,Cynthia Flynn,Cynthia Flynn,Paula Moreci,Douglas E. Williamson,Neal D. Ryan +9 more
TL;DR: Results suggest the K-SADS-PL generates reliable and valid child psychiatric diagnoses.
Journal ArticleDOI
Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene
Avshalom Caspi,Karen Sugden,Terrie E. Moffitt,Alan Taylor,Ian W. Craig,Hona Lee Harrington,Joseph L. McClay,Jonathan Mill,Judy Martin,Antony W. Braithwaite,Richie Poulton +10 more
TL;DR: Evidence of a gene-by-environment interaction is provided, in which an individual's response to environmental insults is moderated by his or her genetic makeup.
Journal ArticleDOI
Role of Genotype in the Cycle of Violence in Maltreated Children
Avshalom Caspi,Avshalom Caspi,Joseph L. McClay,Terrie E. Moffitt,Terrie E. Moffitt,Jonathan Mill,Judy Martin,Ian W. Craig,Alan Taylor,Richie Poulton +9 more
TL;DR: In this paper, a large sample of male children from birth to adulthood was studied to determine why some children who are maltreated grow up to develop antisocial behavior, whereas others do not.
Journal ArticleDOI
The British Child and Adolescent Mental Health Survey 1999: The Prevalence of DSM-IV Disorders
TL;DR: Roughly 1 in 10 children have at least one DSM-IV disorder, involving a level of distress or social impairment likely to warrant treatment, and comorbidity reported between some childhood diagnoses may be due to the association of both disorders with a third.
Journal Article
Association of attention-deficit disorder and the dopamine transporter gene.
Edwin H. Cook,Mark A. Stein,Matthew D. Krasowski,Nancy J. Cox,D M Olkon,J E Kieffer,Bennett L. Leventhal +6 more
TL;DR: In this paper, a haplotype-based haplotype relative risk (HHRR) method was used to test for association between a VNTR polymorphism at the dopamine transporter locus (DAT1) and DSM-III-R-diagnosed ADHD and undifferentiated attention-deficit disorder (UADD) in trios composed of father, mother, and affected offspring.
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