抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

I have developed "tennis elbow" from lugging this book around the past four weeks, but it is worth the pain, the effort, and the aspirin. It is also worth the (relatively speaking) bargain price. Including appendixes, this book contains 894 pages of text. The entire panorama of the neural sciences is surveyed and examined, and it is comprehensive in its scope, from genomes to social behaviors. The editors explicitly state that the book is designed as "an introductory text for students of biology, behavior, and medicine," but it is hard to imagine any audience, interested in any fragment of neuroscience at any level of sophistication, that would not enjoy this book. The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or

Principles of Neural Science

Applied Numerical Analysis. By C.F. Gerald. Pp. xii, 340. £3·60. 1970. (Addison-Wesley.)

A comprehensive review of lithium-ion batteries used in hybrid and electric vehicles at cold temperatures

This paper presents results obtained from monitoring a 1.72 kWp photovoltaic system installed on a flat roof of a 12 m high building in Dublin, Ireland (latitude 53.4°N and longitude 6.3°E). The system was monitored between November 2008 and October 2009 and all the electricity generated was fed into the low voltage supply to the building. Monthly average daily and annual performance parameters of the PV system evaluated include: final yield, reference yield, array yield, system losses, array capture losses, cell temperature losses, PV module efficiency, system efficiency, inverter efficiency, performance ratio and capacity factor. The maximum solar radiation, ambient temperature and PV module temperature recorded were 1241 W/m2 in March, 29.5 °C and 46.9 °C in June respectively. The annual total energy generated was 885.1 kW h/kWp while the annual average daily final yield, reference yield and array yield were 2.41 kW h/kWp/day, 2.85 kW h/kWp/day and 2.62 kW h/kWp/day respectively. The annual average daily PV module efficiency, system efficiency and inverter efficiency were 14.9%, 12.6% and 89.2% respectively while the annual average daily performance ratio and capacity factor were 81.5% and 10.1% respectively. The annual average daily system losses, capture losses and cell temperature losses were 0.23 h/day, 0.22 h/day and 0.00 h/day respectively. Comparison of this system with other systems in different locations showed that the system had the highest annual average daily PV module efficiency, system efficiency and performance ratio of 14.9%, 12.6% and 81.5% respectively. The PV system’s annual average daily final yield of 2.4 kW h/kWp/day is higher than those reported in Germany, Poland and Northern Ireland. It is comparable to results from some parts of Spain but it is lower than the reported yields in most parts of Italy and Spain. Despite low insolation levels, high average wind speeds and low ambient temperature improve Ireland’s suitability.

Measured Performance of a 1.72 kW Rooftop Grid Connected Photovoltaic System in Ireland

In this paper different topologies of populations of FitzHugh–Nagumo neurons have been introduce to investigate the effect of high-frequency driving on the response of neuron populations to a subthreshold low-frequency signal. We show that optimal amplitude of high-frequency driving enhances the response of neuron populations to a subthreshold low-frequency input and the optimal amplitude dependences on the connection among the neurons. By analyzing several kinds of topology (i.e., random and small world) different behaviors have been observed. Several topologies behave in an optimal way with respect to the range of low-frequency amplitude leading to an improvement in the stimulus response coherence, while others with respect to the maximum values of the performance index. However, the best results in terms of both the suitable amplitude of high-frequency driving and high stimulus response coherence have been obtained when the neurons have been connected in a small-world topology.

/pdf/vibrational-resonance-in-neuron-populations-1wlpw9c94a.pdf

Vibrational resonance in neuron populations

We investigate the chaotic phase synchronization in a system of coupled bursting neurons in small-world networks. A transition to mutual phase synchronization takes place on the bursting time scale of coupled oscillators, while on the spiking time scale, they behave asynchronously. It is shown that phase synchronization is largely facilitated by a large fraction of shortcuts, but saturates when it exceeds a critical value. We also study the external chaotic phase synchronization of bursting oscillators in the small-world network by a periodic driving signal applied to a single neuron. It is demonstrated that there exists an optimal small-world topology, resulting in the largest peak value of frequency locking interval in the parameter plane, where bursting synchronization is maintained, even with the external driving. The width of this interval increases with the driving amplitude, but decrease rapidly with the network size. We infer that the externally applied driving parameters outside the frequency locking region can effectively suppress pathologically synchronized rhythms of bursting neurons in the brain.

/pdf/chaotic-phase-synchronization-in-small-world-networks-of-56ti7s8a02.pdf

Chaotic phase synchronization in small-world networks of bursting neurons

The synchronization of neurons coupled with gap junction in the condition of external electrical stimulation is investigated. In this paper, the coupled model is established on the basis of the nonlinear cable equation, and then the relation of coupling strength of the gap junction and the synchronization is discussed in detail. The sufficient condition of complete synchronization is obtained from rigorous mathematical derivation. The synchronizations of periodic neurons and chaotic neurons are studied, respectively.

Chaotic synchronization of neurons coupled with gap junction under external electrical stimulation

A new algorithm for self tuning of proportional-integral-derivative (PID) controllers is proposed. A combined least-squares estimation and Newton-Raphson search technique is used to determine the ultimate gain and period of an unknown system for the purpose of automatic tuning of PID controllers based on Ziegler and Nichols (ZN) or refined Ziegler and Nichols (RZN) formulas. The proposed algorithm can be applied to systems with known time delay, as well as those with unknown dead time. Simulation studies are used to demonstrate the performance of this algorithm. The performance of this PID self tuner is also compared with a popular commercial auto-tuner for simulated systems and a laboratory-scale real plant.

K.M. Tsang

Papers

Vibrational resonance in neuron populations

Chaotic phase synchronization in small-world networks of bursting neurons

Chaotic synchronization of neurons coupled with gap junction under external electrical stimulation

Self-tuning PID controller using Newton-Raphson search method

Adaptive backstepping sliding mode control for chaos synchronization of two coupled neurons in the external electrical stimulation