K. Paige Harden

TL;DR: Genetic correlations estimated from genome-wide association studies (GWASs) reveal pervasive pleiotropy across a wide variety of phenotypes, and genomic structural equation modelling (genomic SEM) is introduced, a multivariate method for analysing the joint genetic architecture of complex traits.

TL;DR: The authors used longitudinal data on 7,640 youth from the National Longitudinal Study of Youth Children and Young Adults, a nationally representative sample assessed biennially from 1994 to 2006, to investigate mean age-related changes in self-reports of impulsivity and sensation seeking from ages 12 to 24 years.

TL;DR: When offspring were compared to their own siblings who differed in their exposure to prenatal nicotine, there was no effect of SDP on offspring CP and ODP, and the current analyses imply that important unidentified environmental factors account for the association between SDP and offspring externalizing problems, not teratogenic effects of S DP.

TL;DR: Although risk for substance use across the population may peak during adolescence and early adulthood, this risk may be highest among those who decline more gradually in impulsivity, and individuals who declined more slowly in impulsiveness increased in alcohol, marijuana, and cigarette more rapidly.

TL;DR: The findings suggest that the window of heightened vulnerability to risk-taking during adolescence may be greater in magnitude and more protracted for males than for females.