K. Sreekumaran Nair

TL;DR: It is demonstrated that age-related muscle mitochondrial dysfunction is related to reduced mtDNA and muscle functional changes that are common in the elderly, supporting the oxidative damage theory of aging.

TL;DR: Recommendations are made that daily physical activity or exercise (resistance training, aerobic exercise) should be undertaken by all older people, for as long as possible to help older adults sustain muscle strength and function into older age.

TL;DR: The muscle mitochondrial response to 4 months of aerobic exercise training was similar in all age-groups, although the older people did not have an improvement in insulin sensitivity, and insulin sensitivity improved in younger people but not in middle-aged or older groups.

TL;DR: A novel stable isotope technique was developed to measure in vivo rates of mitochondrial protein synthesis in human skeletal muscle using needle biopsy samples and this technique was applied to elucidate a potential mechanism for the age-related decline in the mitochondrial content and function of skeletal muscle.

TL;DR: A decline in the synthesis rate of myosin heavy chain implies a decreased ability to remodel this important muscle contractile protein and likely contributes to the declining muscle mass and contractile function in the elderly.