O
Olav Rooyackers
Researcher at Karolinska University Hospital
Publications - 181
Citations - 9972
Olav Rooyackers is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: Skeletal muscle & Glutamine. The author has an hindex of 41, co-authored 172 publications receiving 8047 citations. Previous affiliations of Olav Rooyackers include Mayo Clinic & Western General Hospital.
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Journal ArticleDOI
Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19.
Takuya Sekine,André Perez-Potti,Olga Rivera-Ballesteros,Kristoffer Strålin,Jean Baptiste Gorin,Annika Olsson,Sian Llewellyn-Lacey,Habiba Kamal,Gordana Bogdanovic,Sandra Muschiol,David J. Wullimann,Tobias Kammann,Johanna Emgård,Tiphaine Parrot,Elin Folkesson,Olav Rooyackers,Lars Eriksson,Jan-Inge Henter,Anders Sönnerborg,Tobias Allander,Jan Albert,Morten Nielsen,Jonas Klingström,Sara Gredmark-Russ,Niklas K. Björkström,Johan K. Sandberg,David Price,Hans-Gustaf Ljunggren,Soo Aleman,Marcus Buggert +29 more
TL;DR: It is shown that SARS-CoV-2 elicits robust, broad and highly functional memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19.
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Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes.
Nicolas Musi,Michael F. Hirshman,Jonas Nygren,Monika Svanfeldt,Peter Båvenholm,Olav Rooyackers,Gaochao Zhou,Joanne M. Williamson,Olle Ljunqvist,Suad Efendic,David E. Moller,Anders Thorell,Laurie J. Goodyear +12 more
TL;DR: The findings suggest that the metabolic effects of metformin in subjects with type 2 diabetes may be mediated by the activation of AMPK alpha2, which is implicated in the stimulation of glucose uptake into skeletal muscle and the inhibition of liver gluconeogenesis.
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Effect of age on in vivo rates of mitochondrial protein synthesis in human skeletal muscle
TL;DR: A novel stable isotope technique was developed to measure in vivo rates of mitochondrial protein synthesis in human skeletal muscle using needle biopsy samples and this technique was applied to elucidate a potential mechanism for the age-related decline in the mitochondrial content and function of skeletal muscle.
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Effects of aging on in vivo synthesis of skeletal muscle myosin heavy-chain and sarcoplasmic protein in humans
TL;DR: A decline in the synthesis rate of myosin heavy chain implies a decreased ability to remodel this important muscle contractile protein and likely contributes to the declining muscle mass and contractile function in the elderly.
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Effects of the 11β-Hydroxysteroid Dehydrogenase Inhibitor Carbenoxolone on Insulin Sensitivity in Men with Type 2 Diabetes
TL;DR: Inhibition of 11β-HSD1 offers a novel potential therapy to lower intracellular cortisol concentrations and thereby enhance insulin sensitivity and hepatic lipid catabolism in type 2 diabetes, obesity, and hyperlipidemia.