K
K. W. Michael Siu
Researcher at York University
Publications - 220
Citations - 8760
K. W. Michael Siu is an academic researcher from York University. The author has contributed to research in topics: Mass spectrometry & Ion. The author has an hindex of 52, co-authored 219 publications receiving 8381 citations. Previous affiliations of K. W. Michael Siu include National Research Council & University of Hong Kong.
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Journal ArticleDOI
Search for cancer markers from endometrial tissues using differentially labeled tags iTRAQ and cICAT with multidimensional liquid chromatography and tandem mass spectrometry.
Leroi V. DeSouza,Georg Diehl,Mary Joe Rodrigues,Jingzhong Guo,Alexander D. Romaschin,Terence J. Colgan,‡,‖ and,K. W. Michael Siu +6 more
TL;DR: The chaperonin 10 result confirms the earlier observation of overexpression in EmCa tissues using surface-enhanced laser desorption/ionization mass spectrometry, and may confer sufficient selectivity for diagnosing and screening of EmCa.
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Discovery and verification of head-and-neck cancer biomarkers by differential protein expression analysis using iTRAQ labeling, multidimensional liquid chromatography, and tandem mass spectrometry.
Ranju Ralhan,Ranju Ralhan,Leroi V. DeSouza,Ajay Matta,Satyendra C. Tripathi,Shaun Ghanny,Siddartha Datta Gupta,Sudhir Bahadur,K. W. Michael Siu +8 more
TL;DR: Verification of differential expression of YWHAZ, stratifin, and S100-A7 proteins in clinical samples of HNSCCs and paired and non-paired non-cancerous tissues by immunohistochemistry, immunoblotting, and RT-PCR confirmed their overexpression in head-and-neck cancer.
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Molecular radical cations of oligopeptides
TL;DR: An unprecedented method of producing molecular radical cations of oligopeptides in the gas phase has been discovered in this paper, which is similar to those in the metalloradical enzyme process in photosystem II.
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Multiple Reaction Monitoring of mTRAQ-Labeled Peptides Enables Absolute Quantification of Endogenous Levels of a Potential Cancer Marker in Cancerous and Normal Endometrial Tissues
Leroi V. DeSouza,Adrian M. Taylor,Wei Li,Marjorie S. Minkoff,Alexander D. Romaschin,Terence J. Colgan,K. W. Michael Siu +6 more
TL;DR: The 4-fold higher level of pyruvate kinase amount in the cancer homogenate reported in this study is considerably higher than the 2-foldHigher ratio reported across 20 cancer samples in the discovery phase with the iTRAQ technique, suggesting that there exists a possibility that the dynamic range of ratios determined by the iTraQ technique may have been compressed.
Journal ArticleDOI
Single-parent evolution algorithm and the optimization of Si clusters.
Ionel Rata,Alexandre A. Shvartsburg,Mihai Horoi,Thomas Frauenheim,K. W. Michael Siu,Koblar A. Jackson +5 more
TL;DR: A novel method for the structural optimization of molecular systems that involves an evolving population in which new members are formed by cutting and pasting operations on existing members is described.