K
K. Yonezawa
Researcher at Ludwig Institute for Cancer Research
Publications - 4
Citations - 854
K. Yonezawa is an academic researcher from Ludwig Institute for Cancer Research. The author has contributed to research in topics: Binding site & SH2 domain. The author has an hindex of 4, co-authored 4 publications receiving 842 citations.
Papers
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Journal ArticleDOI
PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity.
Ritu Dhand,Ian Hiles,George Panayotou,Serge Roche,Michael J. Fry,Ivan Gout,Nick Totty,Oanh Truong,P Vicendo,K. Yonezawa +9 more
TL;DR: Tryptic phosphopeptide mapping revealed that the same major peptide was phosphorylated in p85 alpha both in vivo in cultured cells and in the purified recombinant enzyme, having implications for the role of inter‐subunit serine phosphorylation in the regulation of the PI 3‐kinase in vivo.
Journal ArticleDOI
PI 3-kinase: structural and functional analysis of intersubunit interactions.
Ritu Dhand,Hara Kenta,Ian Hiles,Benjamin D. Bax,Ivan Gout,George Panayotou,Michael J. Fry,K. Yonezawa,M. Kasuga,Mike Waterfield +9 more
TL;DR: The predicted structure of p85 suggests a basis for the intersubunit interaction and the relevance of this interaction with respect to the regulation of the PI 3‐kinase complex is discussed.
Journal ArticleDOI
A biosensor approach to probe the structure and function of the p85-alpha-subunit of the phosphatidylinositol 3-kinase complex
P. End,Ivan Gout,Michael J. Fry,George Panayotou,Ritu Dhand,K. Yonezawa,M. Kasuga,Mike Waterfield +7 more
TL;DR: Real-time binding experiments using phospholipid-containing vesicles showed that p85 alpha by itself could specifically bind certain phospholipsids and the relevance of these observations to understanding the relationship of structure to function of p85 and the phosphatidylinositol 3-kinase are discussed.
Patent
Identification and functional characterization of a novel ribosomal S6 protein kinase
TL;DR: A novel S6 kinase, p70βS6k, was described in this paper, along with methods of making and using it and related nucleic acids, and methods of identifying agents which modulate the activity of p70αS6K and/or its ligands.