I
Ian Hiles
Researcher at Ludwig Institute for Cancer Research
Publications - 27
Citations - 4955
Ian Hiles is an academic researcher from Ludwig Institute for Cancer Research. The author has contributed to research in topics: Protein subunit & Kinase. The author has an hindex of 15, co-authored 27 publications receiving 4906 citations. Previous affiliations of Ian Hiles include University College London.
Papers
More filters
Journal ArticleDOI
Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system.
Mark A. Marchionni,Andrew Goodearl,Maio Su Chen,Olivia Bermingham-McDonogh,Cassandra Kirk,Marvin Hendricks,Frank Danehy,Don Misumi,Judith Sudhalter,Kazumi Kobayashi,Diana Wroblewski,Catherine Lynch,Mark Baldassare,Ian Hiles,John B. Davis,John B. Davis,J. Justin Hsuan,Nicholas F. Totty,Masayuki Otsu,Robert N. McBurney,Michael D. Waterfield,Paul Stroobant,David I. Gwynne +22 more
TL;DR: Alternative splicing of the messenger RNA generates an array of putative membrane-attached, intracellular and secreted signalling proteins, at least some of which are expressed in the developing spinal cord and brain.
Journal ArticleDOI
Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase.
Masayuki Otsu,Ian Hiles,Ivan Gout,Michael J. Fry,Fernanda Ruiz-Larrea,George Panayotou,Andrew J. Thompson,Ritu Dhand,J. Justin Hsuan,Nicholas F. Totty,Anthony D. Smith,Sarah J. Morgan,Sara A. Courtneidge,Peter J. Parker,Michael D. Waterfield +14 more
TL;DR: The active PI3-kinase complex containing p85 alpha or p85 beta and the 110 kd protein binds to PDGF but not EGF receptors, suggesting that p85alpha and p85beta may mediate specific PI3 -kinase interactions with a subset of tyrosine kinases.
Journal ArticleDOI
Phosphatidylinositol 3-kinase : structure and expression of the 110 kd catalytic subunit
Ian Hiles,Masayuki Otsu,Stefano Volinia,Michael J. Fry,Ivan Gout,Ritu Dhand,George Panayotou,Fernanda Ruiz-Larrea,Andrew J. Thompson,Nicholas F. Totty,J. Justin Hsuan,Sara A. Courtneidge,Peter J. Parker,Michael D. Waterfield,Michael D. Waterfield +14 more
TL;DR: The characterization of the p110 subunit of Purified bovine brain phosphatidylinositol 3-kinase reveals p110 to be a 1068 aa protein related to Vps34p, a S. cerevisiae protein involved in the sorting of proteins to the vacuole.
Journal ArticleDOI
Phospholipase D: a downstream effector of ARF in granulocytes
Shamshad Cockcroft,Geraint M.H. Thomas,Amanda Fensome,Blandine Geny,Emer Cunningham,Ivan Gout,Ian Hiles,Nicholas F. Totty,Oanh Truong,J. Justin Hsuan +9 more
TL;DR: Results indicate that phospholipase D is a downstream effector of ARF1 and ARF3, which would suggest that alterations in lipid content by PLD are an important determinant in vesicular dynamics.
Journal ArticleDOI
The GTPase dynamin binds to and is activated by a subset of SH3 domains.
Ivan Gout,Ritu Dhand,Ian Hiles,Michael J. Fry,George Panayotou,Pamela Das,Oanh Truong,Nicholas F. Totty,J. Justin Hsuan,Grant W. Booker,Iain D. Campbell,Michael D. Waterfield,Michael D. Waterfield +12 more
TL;DR: Dynamin GTPase activity is stimulated by several of the bound SH3 domains, suggesting that the function of the SH3 module is not restricted to protein-protein interactions but may also include the interactive regulation of GTP-binding proteins.