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Kaarle Franssila

Researcher at University of Helsinki

Publications -  108
Citations -  9182

Kaarle Franssila is an academic researcher from University of Helsinki. The author has contributed to research in topics: Mantle cell lymphoma & Lymphoma. The author has an hindex of 48, co-authored 108 publications receiving 8863 citations. Previous affiliations of Kaarle Franssila include Helsinki University Central Hospital.

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The role of microRNA genes in papillary thyroid carcinoma

TL;DR: It is concluded that up-regulation of several miRs and regulation of KIT are involved in PTC pathogenesis, and that sequence changes in genes targeted by miRNAs can contribute to their regulation.
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Occult papillary carcinoma of the thyroid. A “normal” finding in finland. A systematic autopsy study

TL;DR: According to the study, OPC can be regarded as a normal finding which should not be treated when incidentally found and in order to avoid unnecessary operations it is suggested that incidentally found small OPCs were called occult papillary tumor instead of carcinoma.
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Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma

TL;DR: The data suggest that a common polymorphism in pre-miR-146a affects the miR expression, contributes to the genetic predisposition to PTC, and plays a role in the tumorigenesis through somatic mutation.
Journal Article

Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma.

TL;DR: The finding suggest that loss of Bax immunostaining represents a novel prognostic indicator of poor response to chemotherapy and shorter survival in women with metastatic breast cancer, and raise the possibility that the subgroup of women with Bax-negative tumors may benefit from more aggressive therapy.