K
Kaarle Franssila
Researcher at University of Helsinki
Publications - 108
Citations - 9182
Kaarle Franssila is an academic researcher from University of Helsinki. The author has contributed to research in topics: Mantle cell lymphoma & Lymphoma. The author has an hindex of 48, co-authored 108 publications receiving 8863 citations. Previous affiliations of Kaarle Franssila include Helsinki University Central Hospital.
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Journal ArticleDOI
The role of microRNA genes in papillary thyroid carcinoma
Hulling He,Krystian Jazdzewski,W. G. Li,Sandya Liyanarachchi,Rebecca Nagy,Stefano Volinia,George A. Calin,Chang Gong Liu,Kaarle Franssila,Saul Suster,Richard T. Kloos,Carlo M. Croce,Albert de la Chapelle +12 more
TL;DR: It is concluded that up-regulation of several miRs and regulation of KIT are involved in PTC pathogenesis, and that sequence changes in genes targeted by miRNAs can contribute to their regulation.
Journal ArticleDOI
Occult papillary carcinoma of the thyroid. A “normal” finding in finland. A systematic autopsy study
TL;DR: According to the study, OPC can be regarded as a normal finding which should not be treated when incidentally found and in order to avoid unnecessary operations it is suggested that incidentally found small OPCs were called occult papillary tumor instead of carcinoma.
Journal ArticleDOI
Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma
Krystian Jazdzewski,Elizabeth L. Murray,Kaarle Franssila,Barbara Jarzab,Daniel R. Schoenberg,Albert de la Chapelle +5 more
TL;DR: The data suggest that a common polymorphism in pre-miR-146a affects the miR expression, contributes to the genetic predisposition to PTC, and plays a role in the tumorigenesis through somatic mutation.
Journal Article
Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma.
Stanislaw Krajewski,Carl Blomqvist,Kaarle Franssila,Maryla Krajewska,Veli-Matti Wasenius,Eero Niskanen,Stig Nordling,John C. Reed +7 more
TL;DR: The finding suggest that loss of Bax immunostaining represents a novel prognostic indicator of poor response to chemotherapy and shorter survival in women with metastatic breast cancer, and raise the possibility that the subgroup of women with Bax-negative tumors may benefit from more aggressive therapy.
Journal ArticleDOI
Clinical presentation, course, and prognostic factors in lymphocyte-predominant Hodgkin's disease and lymphocyte-rich classical Hodgkin's disease: report from the European Task Force on Lymphoma Project on Lymphocyte-Predominant Hodgkin's Disease.
Volker Diehl,M Sextro,Jeremy Franklin,Martin-Leo Hansmann,Nancy L. Harris,Elaine S. Jaffe,Sibrand Poppema,Martin Harris,Kaarle Franssila,Jan H.J.M. van Krieken,Theresa Marafioti,Ioannis Anagnostopoulos,Harald Stein +12 more
TL;DR: The two subgroups of LPHD and LRCHD bore a close clinical resemblance that was distinct from CHD; the course was similar to that of comparable nodular sclerosis and mixed cellularity patients.