S
Stefano Volinia
Researcher at University of Ferrara
Publications - 320
Citations - 54046
Stefano Volinia is an academic researcher from University of Ferrara. The author has contributed to research in topics: microRNA & Cancer. The author has an hindex of 86, co-authored 309 publications receiving 51422 citations. Previous affiliations of Stefano Volinia include Case Western Reserve University & Beth Israel Deaconess Medical Center.
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Journal ArticleDOI
A microRNA expression signature of human solid tumors defines cancer gene targets
Stefano Volinia,George A. Calin,Chang Gong Liu,Stefan Ambs,Amelia Cimmino,Fabio Petrocca,Rosa Visone,Marilena V. Iorio,Claudia Roldo,Manuela Ferracin,Robyn L. Prueitt,Nozumu Yanaihara,Giovanni Lanza,Aldo Scarpa,Andrea Vecchione,Massimo Negrini,Curtis C. Harris,Carlo M. Croce +17 more
TL;DR: The results indicate that miRNAs are extensively involved in cancer pathogenesis of solid tumors and support their function as either dominant or recessive cancer genes.
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MicroRNA gene expression deregulation in human breast cancer.
Marilena V. Iorio,Manuela Ferracin,Chang Gong Liu,Angelo Veronese,Riccardo Spizzo,Silvia Sabbioni,Eros Magri,Massimo Pedriali,Muller Fabbri,Manuela Campiglio,Sylvie Ménard,Juan P. Palazzo,Anne L. Rosenberg,Piero Musiani,Stefano Volinia,Italo Nenci,George A. Calin,Patrizia Querzoli,Massimo Negrini,Carlo M. Croce +19 more
TL;DR: It is shown that, compared with normal breast tissue, miRNAs are also aberrantly expressed in human breast cancer, and the overall miRNA expression could clearly separate normal versus cancer tissues, with the most significantly deregulated mi RNAs being mir-125b, mir-145, mir -21, and mir-155.
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miR-15 and miR-16 induce apoptosis by targeting BCL2.
Amelia Cimmino,George A. Calin,Muller Fabbri,Marilena V. Iorio,Manuela Ferracin,Masayoshi Shimizu,Sylwia E. Wojcik,Rami I. Aqeilan,Simona Zupo,Mariella Dono,Laura Z. Rassenti,Hansjuerg Alder,Stefano Volinia,Chang Gong Liu,Thomas J. Kipps,Massimo Negrini,Massimo Negrini,Carlo M. Croce +17 more
TL;DR: It is demonstrated thatmiR-15a and miR-16-1 expression is inversely correlated to Bcl2 expression in CLL and that both microRNAs negatively regulate BCL2 at a posttranscriptional level and are natural antisense B cl2 interactors that could be used for therapy of Bcl1-overexpressing tumors.
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A MicroRNA Signature Associated with Prognosis and Progression in Chronic Lymphocytic Leukemia
George A. Calin,Manuela Ferracin,Manuela Ferracin,Amelia Cimmino,Gianpiero Di Leva,Masayoshi Shimizu,Sylwia E. Wojcik,Marilena V. Iorio,Rosa Visone,Nurettin Ilfer Sever,Muller Fabbri,Muller Fabbri,Rodolfo Iuliano,Tiziana Palumbo,Flavia Pichiorri,Claudia Roldo,Ramiro Garzon,Cinzia Sevignani,Laura Z. Rassenti,Hansjuerg Alder,Stefano Volinia,Chang Gong Liu,Thomas J. Kipps,Massimo Negrini,Carlo M. Croce +24 more
TL;DR: A unique microRNA signature is associated with prognostic factors and disease progression in CLL, and a germ-line mutation in the miR-16-1-miR-15a primary precursor caused low levels of microRNA expression in vitro and in vivo and was associated with deletion of the normal allele.
Journal ArticleDOI
MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B.
Muller Fabbri,Ramiro Garzon,Amelia Cimmino,Amelia Cimmino,Zhongfa Liu,Nicola Zanesi,Elisa Callegari,Shujun Liu,Hansjuerg Alder,Stefan Costinean,Cecilia Fernandez-Cymering,Stefano Volinia,Gulnur Guler,Carl Morrison,Kenneth K. Chan,Guido Marcucci,George A. Calin,Kay Huebner,Carlo M. Croce +18 more
TL;DR: The enforced expression of miR-29s in lung cancer cell lines restores normal patterns of DNA methylation, induces reexpression of methylation-silenced tumor suppressor genes, and inhibits tumorigenicity in vitro and in vivo.