H
Helena Isoniemi
Researcher at University of Helsinki
Publications - 229
Citations - 9257
Helena Isoniemi is an academic researcher from University of Helsinki. The author has contributed to research in topics: Liver transplantation & Transplantation. The author has an hindex of 42, co-authored 208 publications receiving 8368 citations. Previous affiliations of Helena Isoniemi include Helsinki University Central Hospital.
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A blinded, randomized clinical trial of mycophenolate mofetil for the prevention of acute rejection in cadaveric renal transplantation
Paul Keown,Pekka Häyry,Peter J. Morris,Calvin R. Stiller,Christopher M. Barker,Lisa Carr,David Landsberg,Ian R. Hardie,Russell J. Rigby,Helena Isoniemi,Derek W. R. Gray,Philip Belitsky,Allan McDonald,Tim Mathew,A. Clarkson,L. Barratt,B. Buchholz,Rowan Walker,Günther Kirste,Norman Muirhead,David J. Tiller,Geoff Duggin,Philip F. Halloran,Pierre Daloze,Gilles St. Louis,David Russell,David Ludwin,P. Vialtel,U. Binswanger,J. A C Buckels,Jean Louis Touraine,David P. Hickey,Giuseppe Remuzzi,Giuseppe Locatelli,F. T. Lam,Ed Tapper +35 more
TL;DR: MMF is associated with a significantly lower rate of treatment failure compared with AZA during the first 6 months after renal transplantation and produces a clinically important reduction in the incidence, severity, and treatment of acute graft rejection.
Journal ArticleDOI
Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
Tuomas Tammela,Georgia Zarkada,Elisabet Wallgard,Aino Murtomäki,Steven Suchting,Maria Wirzenius,Marika Waltari,Mats Hellström,Tibor Schomber,Reetta Peltonen,Catarina Freitas,Antonio Duarte,Helena Isoniemi,Pirjo Laakkonen,Gerhard Christofori,Seppo Ylä-Herttuala,Masabumi Shibuya,Bronislaw Pytowski,Anne Eichmann,Christer Betsholtz,Kari Alitalo +20 more
TL;DR: It is demonstrated that VEGFR-3 is highly expressed in angiogenic sprouts, and genetic targeting or blocking of VEG FR-3 signalling with monoclonal antibodies results in decreased sprouting, vascular density, vessel branching and endothelial cell proliferation in mouse angiogenesis models, implicate VEGfr-3 as a regulator of vascular network formation.
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High-volume plasma exchange in patients with acute liver failure: An open randomised controlled trial
Fin Stolze Larsen,Lars E. Schmidt,Christine Bernsmeier,Allan Rasmussen,Helena Isoniemi,Vishal C. Patel,Evangelos Triantafyllou,William Bernal,Georg Auzinger,Debbie L. Shawcross,Martin Eefsen,Peter Nissen Bjerring,Jens Otto Clemmesen,Krister Höckerstedt,Hans-Jørgen Frederiksen,Bent Adel Hansen,Charalambos G. Antoniades,Julia Wendon +17 more
TL;DR: Treatment with HVP improves outcome in patients with ALF by increasing liver transplantation-free survival by attributable to attenuation of innate immune activation and amelioration of multi-organ dysfunction.
Journal ArticleDOI
Chronic Allograft Rejection
P. Häyry,Helena Isoniemi,Serdar Yilmaz,Ari Mennander,Karl B. Lemström,Anne Räisänen-Sokolowski,Petri Koskinen,Jarkko Ustinov,Irmelt Lautenschlager,Eero Taskinen,Leena Krogerus,P Aho,Timo Paavonen +12 more
Journal ArticleDOI
Delayed introduction of reduced-dose tacrolimus, and renal function in liver transplantation: the 'ReSpECT' study.
James Neuberger,Richard D. Mamelok,Peter Neuhaus,Jacques Pirenne,Didier Samuel,Helena Isoniemi,Lionel Rostaing,Antonio Rimola,Sally M. Marshall,A. D Mayer +9 more
TL;DR: In conclusion, daclizumab induction, MMF, corticosteroids and delayed reduced‐dose tacrolimus was associated with less nephrotoxicity than therapy with standard‐dosage tacolimus and cortiosteroids without compromising efficacy or tolerability.