K
Kajan Ratnakumar
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 3
Citations - 302
Kajan Ratnakumar is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Metastasis & Phenotype. The author has an hindex of 3, co-authored 3 publications receiving 240 citations.
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Journal ArticleDOI
Microenvironment-derived factors driving metastatic plasticity in melanoma
Isabella S. Kim,Silja Heilmann,Emily R. Kansler,Yan Zhang,Milena A. Zimmer,Kajan Ratnakumar,Robert L. Bowman,Theresa Simon-Vermot,Myles Fennell,Ralph Garippa,Liang Lu,William Lee,Travis J. Hollmann,Joao B. Xavier,Richard M. White +14 more
TL;DR: It is demonstrated that after metastatic dissemination, the microenvironment provides signals to promote phenotype switching and provide proof that targeting tumour cell plasticity is a viable therapeutic opportunity.
Journal ArticleDOI
A Quantitative System for Studying Metastasis Using Transparent Zebrafish
Silja Heilmann,Kajan Ratnakumar,Erin M. Langdon,Emily R. Kansler,Isabella S. Kim,Nathaniel R. Campbell,Elizabeth B. Perry,Amy J. McMahon,Amy J. McMahon,Charles K. Kaufman,Ellen van Rooijen,Ellen van Rooijen,Ellen van Rooijen,William Lee,Christine A. Iacobuzio-Donahue,Richard O. Hynes,Richard O. Hynes,Leonard I. Zon,Joao B. Xavier,Richard M. White,Richard M. White +20 more
TL;DR: In this article, a high-throughput zebrafish system for comprehensive, in vivo assessment of metastatic biology is described. But the method is not suitable for other tumor types and thus serves to complement studies also employing murine and human cell culture systems.
A Quantitative System for Studying Metastasis Using Transparent Zebrafish
Silja Heilmann,Kajan Ratnakumar,Erin M Langdon,Emily R. Kansler,Isabella S. Kim,Nathaniel R. Campbell,Elizabeth B. Perry,Charles K. Kaufman,E. van Rooijen,William Lee,Christine A. Iacobuzio-Donahue,Leonard I. Zon,Joao B. Xavier,Richard M. White,Richard O. Hynes,Amy J. McMahon +15 more
TL;DR: A high-throughput zebrafish system for comprehensive, in vivo assessment of metastatic biology is described and it is determined that the degree of pigmentation is a key feature defining cells with metastatic capability.