E
Ellen van Rooijen
Researcher at Howard Hughes Medical Institute
Publications - 28
Citations - 1792
Ellen van Rooijen is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Zebrafish & Melanoma. The author has an hindex of 19, co-authored 28 publications receiving 1482 citations. Previous affiliations of Ellen van Rooijen include Utrecht University & Royal Netherlands Academy of Arts and Sciences.
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Journal ArticleDOI
A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation
Charles K. Kaufman,Christian Mosimann,Zi Peng Fan,Song Yang,Song Yang,Andrew Thomas,Julien Ablain,Julien Ablain,Justin L. Tan,Rachel D. Fogley,Ellen van Rooijen,Ellen van Rooijen,Elliott J. Hagedorn,Elliott J. Hagedorn,Christie Ciarlo,Christie Ciarlo,Richard M. White,Dominick A. Matos,Ann-Christin Puller,Cristina Santoriello,Cristina Santoriello,Eric C. Liao,Richard A. Young,Leonard I. Zon +23 more
TL;DR: A crestin:EGFP reporter is developed that recapitulates the embryonic neural crest expression pattern of crestin and its expression in melanoma tumors, and shows the importance of NCP-state reemergence as a key event in melanomas initiation from a field of cancer-prone melanocytes.
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Genetic analysis of von Hippel-Lindau disease.
Morgan Nordstrom-O'Brien,Rob B. van der Luijt,Ellen van Rooijen,Ans M.W. van den Ouweland,Danielle Majoor-Krakauer,Martijn P. Lolkema,Aram S. A. van Brussel,Emile E. Voest,Rachel H. Giles +8 more
TL;DR: A comprehensive mutation table of 1,548 germline and somatic VHL mutations, derived from this protein of only 213 amino acids is compiled, intended to facilitate research and function as a necessary adjunct for physicians when providing patient information.
Journal ArticleDOI
Zebrafish mutants in the von Hippel-Lindau tumor suppressor display a hypoxic response and recapitulate key aspects of Chuvash polycythemia
Ellen van Rooijen,Ellen van Rooijen,Emile E. Voest,Ive Logister,Ive Logister,Jeroen Korving,Thorsten Schwerte,Stefan Schulte-Merker,Rachel H. Giles,Fredericus J.M. van Eeden +9 more
TL;DR: It is concluded that VHL participates in regulating hematopoiesis and erythroid differentiation, and zebrafish vhl mutants are the most accurate model for VHL-associated polycythemia to date.
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Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma
Yong Yu,Kolja Schleich,Bin Yue,Sujuan Ji,Philipp Lohneis,Kristel Kemper,Mark R. Silvis,Nouar Qutob,Ellen van Rooijen,Ellen van Rooijen,Melanie Werner-Klein,Lianjie Li,Dhriti Dhawan,Svenja Meierjohann,Maurice Reimann,Abdel G. Elkahloun,Steffi Treitschke,Bernd Dörken,Bernd Dörken,Christian Speck,Frédérick A. Mallette,Leonard I. Zon,Leonard I. Zon,Sheri L. Holmen,Daniel S. Peeper,Yardena Samuels,Clemens A. Schmitt,Clemens A. Schmitt,Soyoung Lee,Soyoung Lee +29 more
TL;DR: A large subset of established melanoma cell lines and primary human melanoma samples presented with a collective upregulation of related and unrelated H3K9 demethylase activities, whose targeted inhibition restored senescence, even in Braf inhibitor-resistant melanomas, evoked secondary immune effects and controlled tumor growth in vivo.
Journal ArticleDOI
A Quantitative System for Studying Metastasis Using Transparent Zebrafish
Silja Heilmann,Kajan Ratnakumar,Erin M. Langdon,Emily R. Kansler,Isabella S. Kim,Nathaniel R. Campbell,Elizabeth B. Perry,Amy J. McMahon,Amy J. McMahon,Charles K. Kaufman,Ellen van Rooijen,Ellen van Rooijen,Ellen van Rooijen,William Lee,Christine A. Iacobuzio-Donahue,Richard O. Hynes,Richard O. Hynes,Leonard I. Zon,Joao B. Xavier,Richard M. White,Richard M. White +20 more
TL;DR: In this article, a high-throughput zebrafish system for comprehensive, in vivo assessment of metastatic biology is described. But the method is not suitable for other tumor types and thus serves to complement studies also employing murine and human cell culture systems.