K
Kakularam Kumar Reddy
Researcher at University of Hyderabad
Publications - 4
Citations - 205
Kakularam Kumar Reddy is an academic researcher from University of Hyderabad. The author has contributed to research in topics: Virtual screening & Binding site. The author has an hindex of 4, co-authored 4 publications receiving 162 citations.
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Journal ArticleDOI
Structure and Ligand Based Drug Design Strategies in the Development of Novel 5-LOX Inhibitors
TL;DR: A comprehensive review on structure based drug design strategies in the development of novel 5-LOX inhibitors is presented in this article.
Journal ArticleDOI
Exploration of binding site pattern in arachidonic acid metabolizing enzymes, Cyclooxygenases and Lipoxygenases
Kakularam Kumar Reddy,Veena Kumari Vidya Rajan,Ashish Gupta,Polamarasetty Aparoy,Pallu Reddanna,Pallu Reddanna +5 more
TL;DR: It has been identified that aliphatic and aromatic interactions are the most common in all the enzymes and in addition interactions unique to each one of these enzymes were identified.
Journal ArticleDOI
Pharmacophore modeling and virtual screening for designing potential 5-Lipoxygenase inhibitors
Polamarasetty Aparoy,Kakularam Kumar Reddy,Suresh K. Kalangi,T. Chandramohan Reddy,Pallu Reddanna +4 more
TL;DR: Chemical feature based pharmacophore models of inhibitors of 5-LOX have been developed with the aid of HipHop and HypoGen modules within Catalyst program package and validated, suggesting the usefulness of the model in screening of various small molecule libraries and identification of potential lead compounds for 5- LOX inhibition.
Journal ArticleDOI
CoMFA and CoMSIA studies on 5-hydroxyindole-3-carboxylate derivatives as 5-lipoxygenase inhibitors: generation of homology model and docking studies.
TL;DR: The predictive power of the CoMSIA model was higher than the CoMFA model, the high predictive r(2) values of the test set reveals that the models prove to be useful tools for activity prediction of newly designed 5-LOX inhibitors.