T
T. Chandramohan Reddy
Researcher at University of Hyderabad
Publications - 6
Citations - 362
T. Chandramohan Reddy is an academic researcher from University of Hyderabad. The author has contributed to research in topics: Apoptosis & Virtual screening. The author has an hindex of 6, co-authored 6 publications receiving 319 citations.
Papers
More filters
Journal ArticleDOI
Betanin a betacyanin pigment purified from fruits of Opuntia ficus-indica induces apoptosis in human chronic myeloid leukemia Cell line-K562.
Devalraju Sreekanth,M.K. Arunasree,Karnati R. Roy,T. Chandramohan Reddy,Gorla V. Reddy,Pallu Reddanna +5 more
TL;DR: It is demonstrated that betanin induces apoptosis in K562 cells through the intrinsic pathway and is mediated by the release of cytochrome c from mitochondria into the cytosol, and PARP cleavage.
Journal ArticleDOI
Anti-leukemic effects of gallic acid on human leukemia K562 cells: downregulation of COX-2, inhibition of BCR/ABL kinase and NF-κB inactivation.
T. Chandramohan Reddy,D. Bharat Reddy,A. Aparna,Kalle M. Arunasree,Geetika Gupta,Chandrani Achari,Gorla V. Reddy,V. Lakshmipathi,A. Subramanyam,Pallu Reddanna +9 more
TL;DR: GA induced apoptosis in K562 cells involves death receptor and mitochondrial-mediated pathways by inhibiting BCR/ABL kinase, NF-κB activity and COX-2.
Journal ArticleDOI
Design, synthesis, and biological evaluation of prenylated chalcones as 5-LOX inhibitors.
Nimmanapalli P. Reddy,Polamarasetty Aparoy,T. Chandramohan Reddy,Chandrani Achari,P. Ramu Sridhar,Pallu Reddanna +5 more
TL;DR: Ten novel mono- and di-O-prenylated chalcone derivatives were designed on the basis of a homology derived molecular model of 5-lipoxygenase (5-LOX) and their binding characteristics were quantified using LUDI to verify their inhibitory activities.
Journal ArticleDOI
Pharmacophore modeling and virtual screening for designing potential 5-Lipoxygenase inhibitors
Polamarasetty Aparoy,Kakularam Kumar Reddy,Suresh K. Kalangi,T. Chandramohan Reddy,Pallu Reddanna +4 more
TL;DR: Chemical feature based pharmacophore models of inhibitors of 5-LOX have been developed with the aid of HipHop and HypoGen modules within Catalyst program package and validated, suggesting the usefulness of the model in screening of various small molecule libraries and identification of potential lead compounds for 5- LOX inhibition.
Journal Article
High-throughput screening assays for cyclooxygenase-2 and 5-lipoxygenase, the targets for inflammatory disorders.
K. Anil Kumar,T. Chandramohan Reddy,Gorla V. Reddy,D. Bharat Reddy,Suraneni V.K. Mahipal,Sudhir Sinha,Anil N. Gaikwad,Pallu Reddanna +7 more
TL;DR: In the present study, HTS-compatible assays for COX-1,COX-2 and 5-LOX were developed for screening of compound libraries with the view to identify potential anti-inflammatory drug candidates.