Kanhu Charan Das

TL;DR: The draft genome of Fasciola gigantica presents a comprehensive resource to facilitate the development of novel interventions for fascioliasis control and indicates that the fatty acid required for survival of the fluke may be acquired from the host bile.

TL;DR: The designed peptide-based vaccine construct needs further experimental and clinical investigations to develop it as a safe and effective vaccine against VL infection.

TL;DR: It is shown that quercetin binds in the interacting region between the transmembrane domain and nucleotide-binding domain out of the three plausible binding sites of P-gp and restrict the conformational change from inward- to outward-facing conformation of P -gp.

TL;DR: The current study provided a basis for exploiting regions other than the active site of TGR for inhibitory effect and development of novel antihelminthics and displayed differential dynamics in the FgTGR structure and highlighted the relevance of residue-level interactions in the protein.

TL;DR: Several FgePKs were found to possess unusual domain architectures, which suggests the diverse nature of the proteins that can be exploited for designing novel inhibitors, further providing a platform for novel structure-based drug designing.