Draft Genome of the Liver Fluke Fasciola gigantica
Tripti Pandey,Arpita Ghosh,Vivek N Todur,Vijayakumar R,Parismita Kalita,Jupitara Kalita,Rohit Shukla,Purna B Chetri,Harish Shukla,Amit Sonkar,Denzelle Lee Lyngdoh,Radhika Singh,Heena Khan,Joplin Nongkhlaw,Kanhu Charan Das,Timir Tripathi +15 more
- Vol. 5, Iss: 19, pp 11084-11091
TLDR
The draft genome of Fasciola gigantica presents a comprehensive resource to facilitate the development of novel interventions for fascioliasis control and indicates that the fatty acid required for survival of the fluke may be acquired from the host bile.Abstract:
Fascioliasis, a neglected foodborne disease caused by liver flukes (genus Fasciola), affects more than 200 million people worldwide. Despite technological advances, little is known about the molecu...read more
Citations
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Recent Progress in the Development of Liver Fluke and Blood Fluke Vaccines
TL;DR: The status currently of vaccine development is summarized, some of the major scientific targets for progression are identified and future innovations that may provide effective protective immunity against these helminth parasites and the diseases they cause are discussed.
Journal ArticleDOI
Phosphoglycerate kinase: structural aspects and functions, with special emphasis on the enzyme from Kinetoplastea.
Maura Rojas-Pirela,Diego Andrade-Alviarez,Verónica Rojas,Ulrike Kemmerling,Ana J. Cáceres,Paul A.M. Michels,Juan Luis Concepción,Wilfredo Quiñones +7 more
TL;DR: The overall aspects of this enzyme are highlighted, such as its structure, reaction kinetics, activity regulation and possible moonlighting functions in different protistan organisms, especially both free-living and parasitic Kinetoplastea.
Journal ArticleDOI
Fasciola Species Introgression: Just a Fluke or Something More?
TL;DR: How an increased demand for animal-derived protein, combined with a lack of appropriate tools for detection of these events, is changing the status quo of these zoonotic parasites is highlighted.
Journal ArticleDOI
Identification and characterization of cytosolic malate dehydrogenase from the liver fluke Fasciola gigantica.
TL;DR: The cytosolic malate dehydrogenase in F. gigantica is identified and the enzyme biochemically and structurally characterized and the structural and functional properties of MDH are understood to better understand the roles of this enzyme in the biochemistry of the parasite.
Journal ArticleDOI
Differential expression of microRNAs and tRNA fragments mediate the adaptation of the liver fluke Fasciola gigantica to its intermediate snail and definitive mammalian hosts.
Rui-Si Hu,Xiao-Xuan Zhang,Qiao-Ni Ma,Hany M. Elsheikha,Muhammad Ehsan,Quan Zhao,Bastian Fromm,Xing-Quan Zhu,Xing-Quan Zhu +8 more
TL;DR: In this article, a global analysis of F. gigantica lifecycle stages revealed new roles of miRNAs and tRNA-derived fragments in parasite development and will facilitate future research into understanding of fasciolosis pathobiology.
References
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