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Kanika Varshney

Researcher at Central Drug Research Institute

Publications -  10
Citations -  110

Kanika Varshney is an academic researcher from Central Drug Research Institute. The author has contributed to research in topics: Docking (molecular) & Lead compound. The author has an hindex of 5, co-authored 10 publications receiving 100 citations. Previous affiliations of Kanika Varshney include University of Lucknow & Council of Scientific and Industrial Research.

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Journal ArticleDOI

Pharmacophore-based virtual screening and docking studies on Hsp90 inhibitors.

Shailendra K. Saxena, +3 more
- 04 Sep 2010 - 
TL;DR: The validated pharmacophore model (Hypo-1) was used as a 3D query for virtual screening to retrieve potential inhibitors from the Maybridge and National Cancer Institute databases to confirm that HY, HBA and HBD features are essential for Hsp90 inhibition.
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Toward the Identification of a Reliable 3D QSAR Pharmacophore Model for the CCK2 Receptor Antagonism

Amit K. Gupta, +2 more
- 04 May 2012 - 
TL;DR: This model was validated through F-test and docking studies at the active site of the plausible CCK-2R where the 99% significance and well corroboration with the pharmacophore model respectively describes the model's reliability.
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Identification of Novel Amino Acid Derived CCK-2R Antagonists As Potential Antiulcer Agent: Homology Modeling, Design, Synthesis, and Pharmacology

Amit K. Gupta, +6 more
- 04 Jan 2013 - 
TL;DR: The present study revisited the three-dimensional (3D) homology model of CCK-2R using human A(2a) adenosine receptor and the resolved NMR based structure of the third extracellular loop of the CCK -2R as templates to identify novel antiulcer agents.
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Synthesis, Structure–Activity Relationship and Docking Studies of Substituted Aryl Thiazolyl Phenylsulfonamides as Potential Protein Tyrosine Phosphatase 1B Inhibitors

Kanika Varshney, +7 more
- 01 Jul 2012 - 
TL;DR: Efforts are being made to discover orally active and selective PTP1B inhibitors that could be useful for probing signal transduction pathways as well as for the treatment of diabetes and obesity.
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Identification of novel urea derivatives as PTP1B inhibitors: synthesis, biological evaluation and structure–activity relationships

Swati Gupta, +6 more
- 25 Sep 2013 - 
TL;DR: A series of substituted 1,3-benzyl urea has been synthesized and evaluated for PTP1B inhibitory, antidiabetic and antidyslipidemic activities as mentioned in this paper.