Rohit Srivastava

TL;DR: Glycosyl amino esters on reaction with different isocyanates resulted in quantitative conversion to glycosyl ureas, which exhibited marginal antitubercular activity against Mycobacterium aurum and alpha-glucosidase.

TL;DR: In-vivo silencing of miR-135a alleviated hyperglycemia, improved glucose tolerance and significantly restored the levels of IRS2 and p-Akt in the gastrocnemius skeletal muscle of db/db mice without any effect on their hepatic levels, suggesting that miR -135a targets IRS2 levels by binding to its 3'UTR and this interaction regulates skeletal muscle insulin signaling.

TL;DR: Though most of the compounds exhibited little activity, however, one showed significant activity against all the strains in cell culture and activity was confirmed by B actec method.

TL;DR: A novel link between elevated hepatic miR-22-3p expression and impaired gluconeogenesis in diabetic db/db mice via the regulation of Tcf7 is unraveled via microRNA-mediated regulation of TCF7, and this microRNAs increases the expression of enzymes of the gluconeogenic pathway in HepG2 cells.

TL;DR: A series of 3,5-disubstituted thiadiazine thiones synthesized by reaction of primary amines with carbon disulphide followed by cyclocondensation of the resulting intermediate with formaldehyde and primary amine or amino acids showed antimycobacterial activity in vitro and exhibited activity in vivo.