K
Kanneboyina Nagaraju
Researcher at Binghamton University
Publications - 189
Citations - 9970
Kanneboyina Nagaraju is an academic researcher from Binghamton University. The author has contributed to research in topics: Duchenne muscular dystrophy & Skeletal muscle. The author has an hindex of 52, co-authored 181 publications receiving 8793 citations. Previous affiliations of Kanneboyina Nagaraju include Children's National Medical Center & Johns Hopkins University.
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Journal ArticleDOI
Endothelial cell activation and neovascularization are prominent in dermatomyositis
Kanneboyina Nagaraju,Lisa G. Rider,Chenguang Fan,Yi-Wen Chen,Megan Mitsak,Rashmi Rawat,Kathleen Patterson,Cecilia Grundtman,Frederick W. Miller,Paul H. Plotz,Eric P. Hoffman,Ingrid E. Lundberg +11 more
TL;DR: Gene expression analysis demonstrated that genes that participate not only in angiogenesis but also in leukocyte trafficking and the complement cascade were highly up regulated in DM muscle in comparison to age matched controls.
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Long-term efficacy of systemic multiexon skipping targeting dystrophin exons 45-55 with a cocktail of vivo-morpholinos in mdx52 mice.
Yusuke Echigoya,Yoshitsugu Aoki,Bailey Miskew,Dharminder Panesar,Aleksander Touznik,Tetsuya Nagata,Jun Tanihata,Akinori Nakamura,Kanneboyina Nagaraju,Toshifumi Yokota +9 more
TL;DR: A new regimen with the 10-Vivo-Morpholino cocktail is effective and safe for long-term repeated systemic administration in the dystrophic mouse model and exhibits the restoration of 5-27% of normal levels of dystrophin protein in skeletal muscles, accompanied by improvements in histopathology and muscle strength.
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Novel fragments of the Sjögren's syndrome autoantigens α‐fodrin and type 3 muscarinic acetylcholine receptor generated during cytotoxic lymphocyte granule–induced cell death
TL;DR: The observation that both ubiquitously expressed autoantigens targeted in Sjögren's syndrome are specifically cleaved by granzyme B, generating unique fragments strongly suggests that a common biochemical event is responsible for selecting this apparently unconnected group of molecules for a high-titer autoantibody response.
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Glycogen Stored in Skeletal but Not in Cardiac Muscle in Acid α-Glucosidase Mutant (Pompe) Mice Is Highly Resistant to Transgene-Encoded Human Enzyme
Nina Raben,Tejas Jatkar,Alicia Lee,Nina Lu,Sunita Dwivedi,Kanneboyina Nagaraju,Paul H. Plotz +6 more
TL;DR: It is demonstrated that levels of 20-30% of normal activity are indeed sufficient to clear glycogen in the heart of young Gaa(-/-) mice, but not in older mice with a considerably higher glycogen load, and in skeletal muscle some muscle fibers showed little or no glycogen clearance.
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Enhancing translation: guidelines for standard pre-clinical experiments in mdx mice.
Raffaella Willmann,Annamaria De Luca,Michael Benatar,Miranda D. Grounds,Judith Dubach,Jean-Marc Raymackers,Kanneboyina Nagaraju +6 more
TL;DR: Testing of all new molecules/drugs using a widely accepted and agreed upon standard experimental protocol would greatly improve the power of pre-clinical experimentations and help identifying promising therapies for the translation into clinical trials for boys with Duchenne Muscular Dystrophy.