K
Kanneboyina Nagaraju
Researcher at Binghamton University
Publications - 189
Citations - 9970
Kanneboyina Nagaraju is an academic researcher from Binghamton University. The author has contributed to research in topics: Duchenne muscular dystrophy & Skeletal muscle. The author has an hindex of 52, co-authored 181 publications receiving 8793 citations. Previous affiliations of Kanneboyina Nagaraju include Children's National Medical Center & Johns Hopkins University.
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Journal ArticleDOI
Glucocorticoid efficacy in asthma: is improved tissue remodeling upstream of anti-inflammation.
TL;DR: This work presents an alternative paradigm, where GC efficacy is mediated through more successful tissue remodeling, with reduction in inflammation secondary to successful regeneration.
Journal ArticleDOI
The TREAT-NMD advisory committee for therapeutics (TACT): an innovative de-risking model to foster orphan drug development
Emma Heslop,Cristina Csimma,Volker Straub,John M. McCall,Kanneboyina Nagaraju,Kathryn R. Wagner,Didier Caizergues,Rudolf Korinthenberg,Kevin M. Flanigan,Petra Kaufmann,Elizabeth McNeil,Jerry R. Mendell,Sharon E. Hesterlee,Dominic J. Wells,Kate Bushby +14 more
TL;DR: A number of recurrent themes emerged over the course of the reviews and it was found that applicants frequently require advice and education on issues concerned with preclinical standard operating procedures, interactions with regulatory agencies, formulation, repurposing, clinical trial design, manufacturing and ethics.
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Evaluation of Skeletal and Cardiac Muscle Function after Chronic Administration of Thymosin β-4 in the Dystrophin Deficient Mouse
Christopher F. Spurney,Hee-Jae Cha,Arpana Sali,Gouri S. Pandey,Emidio E. Pistilli,Alfredo D. Guerron,Heather Gordish-Dressman,Eric P. Hoffman,Kanneboyina Nagaraju +8 more
TL;DR: In exercised dystrophin deficient mice, chronic administration of Tβ4 increased the number of regenerating fibers in skeletal muscle and could have a potential role in treatment of skeletal muscle disease in Duchenne muscular dystrophy.
Journal ArticleDOI
Mitochondrial dysfunction and role of harakiri in the pathogenesis of myositis.
Jessica F. Boehler,Jessica F. Boehler,Adam Horn,Adam Horn,James S. Novak,James S. Novak,Ning Li,Svetlana Ghimbovschi,Ingrid E. Lundberg,Ingrid E. Lundberg,Helene Alexanderson,Helene Alexanderson,Li Alemo Munters,Jyoti K. Jaiswal,Jyoti K. Jaiswal,Kanneboyina Nagaraju,Kanneboyina Nagaraju +16 more
TL;DR: It is postulate that in individuals with susceptible genetic backgrounds, viral infection alters the epigenome to activate the pathological pathways leading to disease onset and exercise induced reduction of HRK and TLR7 expression in patients is associated with disease amelioration.
Journal ArticleDOI
Pentoxifylline as a rescue treatment for DMD: A randomized double-blind clinical trial
Diana M. Escolar,A. Zimmerman,Tulio E. Bertorini,Paula R. Clemens,Anne M. Connolly,L. Mesa,Ksenija Gorni,Andrew J. Kornberg,Hanna Kolski,Nancy L. Kuntz,Yoram Nevo,Carolina Tesi-Rocha,Kanneboyina Nagaraju,Sree Rayavarapu,Lauren P. Hache,J. Mayhew,J. Florence,F. Hu,Antonio Arrieta,Erik K Henricson,Robert T. Leshner,J. Mah +21 more
TL;DR: The addition of PTX to corticosteroid-treated boys with DMD at a moderate to late ambulatory stage of disease did not improve or halt the deterioration of muscle strength and function over a 12-month study period.