K
Kanneboyina Nagaraju
Researcher at Binghamton University
Publications - 189
Citations - 9970
Kanneboyina Nagaraju is an academic researcher from Binghamton University. The author has contributed to research in topics: Duchenne muscular dystrophy & Skeletal muscle. The author has an hindex of 52, co-authored 181 publications receiving 8793 citations. Previous affiliations of Kanneboyina Nagaraju include Children's National Medical Center & Johns Hopkins University.
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Journal ArticleDOI
Accurate Quantitation of Dystrophin Protein in Human Skeletal Muscle Using Mass Spectrometry.
Kristy J. Brown,Ramya Marathi,Alyson A. Fiorillo,Eugene F. Ciccimaro,Seema Sharma,David S. Rowlands,Sree Rayavarapu,Kanneboyina Nagaraju,Eric P. Hoffman,Yetrib Hathout +9 more
TL;DR: The approach uses a combination of stable isotope labeled dystrophin as a spike-in standard, gel electrophoresis and high precision mass spectrometry to detect and quantitate multiple peptides of dyStrophin within a complex protein mixture.
Journal ArticleDOI
Characterization of dysferlin deficient SJL/J mice to assess preclinical drug efficacy: fasudil exacerbates muscle disease phenotype.
Sree Rayavarapu,Sree Rayavarapu,Jack H. Van der Meulen,Heather Gordish-Dressman,Eric P. Hoffman,Eric P. Hoffman,Kanneboyina Nagaraju,Kanneboyina Nagaraju,Susan Knoblach,Susan Knoblach +9 more
TL;DR: These studies provide a basis for standardization of preclinical drug testing trials in the dysferlin deficient SJL/J mice, and identify measures of functional status that are potentially translatable to clinical trial outcomes.
Journal ArticleDOI
Development of autoantibodies against muscle-specific FHL1 in severe inflammatory myopathies
Inka Albrecht,Cecilia Wick,Åsa Hallgren,Anna Tjärnlund,Kanneboyina Nagaraju,Felipe Andrade,Kathryn Thompson,William Coley,Aditi Phadke,Lina-Marcela Diaz-Gallo,Matteo Bottai,Inger Nennesmo,Karine Chemin,Jessica Herrath,Karin Johansson,Anders Wikberg,A. Jimmy Ytterberg,Roman A. Zubarev,Olof Danielsson,Olga Krystufkova,Jiri Vencovsky,Nils Landegren,Nils Landegren,Marie Wahren-Herlenius,Leonid Padyukov,Olle Kämpe,Olle Kämpe,Ingrid E. Lundberg +27 more
TL;DR: It is shown that patients with idiopathic inflammatory myopathies (IIMs) develop autoimmunity to FHL1, which is a muscle-specific protein, and it is determined that FHL 1 is a target of the cytotoxic protease granzyme B, indicating that the generation of F HL1 fragments may initiate FHL2 autoim immunity.
Journal ArticleDOI
Polymyositis and dermatomyositis: pathophysiology.
TL;DR: Combining the autoantibody profiles with molecular signatures of innate and nonimmune mechanisms would enhance the ability to classify, diagnose, and treat these disorders more effectively.
Journal ArticleDOI
Infection-Induced Expansion of a MHC Class Ib-Dependent Intestinal Intraepithelial γδ T Cell Subset
Adrian Davies,Sergio López-Briones,Helena Ong,Cynthia O’Neil-Marshall,François A. Lemonnier,Kanneboyina Nagaraju,Eleanor S. Metcalf,Mark J. Soloski +7 more
TL;DR: The expansion of a CD8αβ+CD94−TCRγδ+ T cell subset within the iIEL population in response to oral infection with virulent or avirulent Salmonella is demonstrated in a mouse model.